Sarah A Gagliano
Overview
Explore the profile of Sarah A Gagliano including associated specialties, affiliations and a list of published articles.
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13
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833
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Recent Articles
1.
Gagliano S, Sengupta S, Sidore C, Maschio A, Cucca F, Schlessinger D, et al.
Genet Epidemiol
. 2018 Dec;
43(1):112-117.
PMID: 30565766
It is unclear whether insertions and deletions (indels) are more likely to influence complex traits than abundant single-nucleotide polymorphisms (SNPs). We sought to understand which category of variation is more...
2.
Hughes C, Choi M, Ryten M, Hopkins L, Drews A, Botia J, et al.
Acta Neuropathol
. 2018 Oct;
137(1):121.
PMID: 30328509
In the original publication of this article, the author Magarida Rodrigues was written incorrectly.
3.
Hughes C, Choi M, Ryten M, Hopkins L, Drews A, Botia J, et al.
Acta Neuropathol
. 2018 Sep;
137(1):103-120.
PMID: 30225556
Despite the wealth of genomic and transcriptomic data in Parkinson's disease (PD), the initial molecular events are unknown. Using LD score regression analysis, we show significant enrichment in PD heritability...
4.
Zhou W, Nielsen J, Fritsche L, Dey R, Gabrielsen M, Wolford B, et al.
Nat Genet
. 2018 Aug;
50(9):1335-1341.
PMID: 30104761
In genome-wide association studies (GWAS) for thousands of phenotypes in large biobanks, most binary traits have substantially fewer cases than controls. Both of the widely used approaches, the linear mixed...
5.
Hernandez-Fuentes M, Franklin C, Rebollo-Mesa I, Mollon J, Delaney F, Perucha E, et al.
Am J Transplant
. 2018 Feb;
18(6):1370-1379.
PMID: 29392897
Improvements in immunosuppression have modified short-term survival of deceased-donor allografts, but not their rate of long-term failure. Mismatches between donor and recipient HLA play an important role in the acute...
6.
Gagliano S, Pouget J, Hardy J, Knight J, Barnes M, Ryten M, et al.
Ann Clin Transl Neurol
. 2017 Jan;
3(12):924-933.
PMID: 28097204
Objectives: We assessed the current genetic evidence for the involvement of various cell types and tissue types in the etiology of neurodegenerative diseases, especially in relation to the neuroinflammatory hypothesis...
7.
Gagliano S
Biol Psychiatry
. 2016 Oct;
81(6):478-483.
PMID: 27788914
What makes the molecular study of psychiatric and other neurological conditions particularly challenging compared with other complex traits is the difficulty of accessing the relevant tissue. The Encyclopedia of DNA...
8.
Gagliano S, Ptak C, Mak D, Shamsi M, Oh G, Knight J, et al.
Am J Hum Genet
. 2016 Apr;
98(5):956-962.
PMID: 27087318
Numerous recent studies have suggested that phenotypic effects of DNA sequence variants can be mediated or modulated by their epigenetic marks, such as allele-skewed DNA modification (ASM). Using Affymetrix SNP...
9.
Gagliano S, Ravji R, Barnes M, Weale M, Knight J
Sci Rep
. 2015 Aug;
5:13373.
PMID: 26300220
Although technology has triumphed in facilitating routine genome sequencing, new challenges have been created for the data-analyst. Genome-scale surveys of human variation generate volumes of data that far exceed capabilities...
10.
Gagliano S, Paterson A, Weale M, Knight J
BMC Genomics
. 2015 May;
16:405.
PMID: 25997848
Background: In silico models have recently been created in order to predict which genetic variants are more likely to contribute to the risk of a complex trait given their functional...