Sarah A Denha
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Explore the profile of Sarah A Denha including associated specialties, affiliations and a list of published articles.
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6
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10
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Recent Articles
1.
Denha S, DeLaet N, Abukamil A, Alexopoulos A, Keller A, Atang A, et al.
bioRxiv
. 2024 Sep;
PMID: 39345584
Spinocerebellar ataxia type 5 (SCA5) mutations in the protein β-III-spectrin cluster to the N-terminal actin-binding domain (ABD) and the central spectrin-repeat domains (SRDs). We previously reported that a common molecular...
2.
Atang A, Keller A, Denha S, Avery A
Cells
. 2023 Aug;
12(16).
PMID: 37626910
Spinocerebellar ataxia type 5 (SCA5) is a neurodegenerative disease caused by mutations in the gene encoding the cytoskeletal protein β-III-spectrin. Previously, we demonstrated that a L253P missense mutation, localizing to...
3.
Atang A, Keller A, Denha S, Avery A
bioRxiv
. 2023 Mar;
PMID: 36865188
Spinocerebellar ataxia type 5 (SCA5) is a neurodegenerative disease caused by mutations in the SPTBN2 gene encoding the cytoskeletal protein β-III-spectrin. Previously, we demonstrated that a L253P missense mutation, localizing...
4.
Guhathakurta P, Rebbeck R, Denha S, Keller A, Carter A, Atang A, et al.
J Biol Chem
. 2023 Feb;
299(3):102956.
PMID: 36731793
β-III-Spectrin is a key cytoskeletal protein that localizes to the soma and dendrites of cerebellar Purkinje cells and is required for dendritic arborization and signaling. A spinocerebellar ataxia type 5...
5.
Denha S, Atang A, Hays T, Avery A
Sci Rep
. 2022 Feb;
12(1):1726.
PMID: 35110634
Recent structural studies of β-III-spectrin and related cytoskeletal proteins revealed N-terminal sequences that directly bind actin. These sequences are variable in structure, and immediately precede a conserved actin-binding domain composed...
6.
Rebbeck R, Andrick A, Denha S, Svensson B, Guhathakurta P, Thomas D, et al.
J Biol Chem
. 2021 Apr;
296:100215.
PMID: 33839680
Numerous diseases are linked to mutations in the actin-binding domains (ABDs) of conserved cytoskeletal proteins, including β-III-spectrin, α-actinin, filamin, and dystrophin. A β-III-spectrin ABD mutation (L253P) linked to spinocerebellar ataxia...