Sara Zocher
Overview
Explore the profile of Sara Zocher including associated specialties, affiliations and a list of published articles.
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Articles
18
Citations
643
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Recent Articles
1.
Zocher S
EMBO J
. 2024 Jul;
43(16):3312-3326.
PMID: 39009672
Aging is associated with a progressive decline of brain function, and the underlying causes and possible interventions to prevent this cognitive decline have been the focus of intense investigation. The...
2.
Zocher S, McCloskey A, Karasinsky A, Schulte R, Friedrich U, Lesche M, et al.
Science
. 2024 Apr;
384(6691):53-59.
PMID: 38574132
Genomic DNA that resides in the nuclei of mammalian neurons can be as old as the organism itself. The life span of nuclear RNAs, which are critical for proper chromatin...
3.
Leiter O, Zhuo Z, Rust R, Wasielewska J, Gronnert L, Kowal S, et al.
Cell Metab
. 2023 Jun;
35(6):1085.
PMID: 37285804
No abstract available.
4.
Lopes J, Malz M, Senko A, Zocher S, Kempermann G
Hippocampus
. 2023 Mar;
33(4):360-372.
PMID: 36880417
There is still limited mechanistic insight into how the interaction of individuals with their environment results in the emergence of individuality in behavior and brain structure. Nevertheless, the idea that...
5.
Zocher S, Toda T
Hippocampus
. 2023 Jan;
33(4):347-359.
PMID: 36624660
Neural stem cells (NSCs) in the hippocampus generate new neurons throughout life, which functionally contribute to cognitive flexibility and mood regulation. Yet adult hippocampal neurogenesis substantially declines with age and...
6.
Kempermann G, Lopes J, Zocher S, Schilling S, Ehret F, Garthe A, et al.
Neurobiol Dis
. 2022 Nov;
175:105916.
PMID: 36336243
Personalized medicine intensifies interest in experimental paradigms that delineate sources of phenotypic variation. The paradigm of environmental enrichment allows for comparisons among differently housed laboratory rodents to unravel environmental effects...
7.
Leiter O, Zhuo Z, Rust R, Wasielewska J, Gronnert L, Kowal S, et al.
Cell Metab
. 2022 Feb;
34(3):408-423.e8.
PMID: 35120590
Although the neurogenesis-enhancing effects of exercise have been extensively studied, the molecular mechanisms underlying this response remain unclear. Here, we propose that this is mediated by the exercise-induced systemic release...
8.
Zocher S, Overall R, Berdugo-Vega G, Rund N, Karasinsky A, Adusumilli V, et al.
EMBO J
. 2021 Aug;
40(18):e107100.
PMID: 34337766
Adult neurogenesis enables the life-long addition of functional neurons to the hippocampus and is regulated by both cell-intrinsic molecular programs and behavioral activity. De novo DNA methylation is crucial for...
9.
Zocher S, Overall R, Lesche M, Dahl A, Kempermann G
Nat Commun
. 2021 Jun;
12(1):3892.
PMID: 34162876
The decline of brain function during aging is associated with epigenetic changes, including DNA methylation. Lifestyle interventions can improve brain function during aging, but their influence on age-related epigenetic changes...
10.
Generation of mouse hippocampal neural precursor cell lines with CRISPR/Cas9-mediated gene knockouts
Zocher S, Kempermann G
STAR Protoc
. 2021 May;
2(2):100472.
PMID: 33948565
Genetic manipulation of neural precursor cells is an important tool to study mechanisms underlying proliferation, fate specification, and neuron formation. The CRISPR/Cas9 system enables efficient genome editing but requires the...