Rupert W Overall
Overview
Explore the profile of Rupert W Overall including associated specialties, affiliations and a list of published articles.
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Articles
41
Citations
839
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Recent Articles
1.
Creating a biomedical knowledge base by addressing GPT inaccurate responses and benchmarking context
Darnell S, Overall R, Guarracino A, Colonna V, Villani F, Garrison E, et al.
bioRxiv
. 2024 Oct;
PMID: 39463999
We created GNQA, a generative pre-trained transformer (GPT) knowledge base driven by a performant retrieval augmented generation (RAG) with a focus on aging, dementia, Alzheimer's and diabetes. We uploaded a...
2.
Niarakis A, Ostaszewski M, Mazein A, Kuperstein I, Kutmon M, Gillespie M, et al.
Front Immunol
. 2024 Feb;
14:1282859.
PMID: 38414974
Introduction: The COVID-19 Disease Map project is a large-scale community effort uniting 277 scientists from 130 Institutions around the globe. We use high-quality, mechanistic content describing SARS-CoV-2-host interactions and develop...
3.
Leiter O, Zhuo Z, Rust R, Wasielewska J, Gronnert L, Kowal S, et al.
Cell Metab
. 2023 Jun;
35(6):1085.
PMID: 37285804
No abstract available.
4.
Kempermann G, Lopes J, Zocher S, Schilling S, Ehret F, Garthe A, et al.
Neurobiol Dis
. 2022 Nov;
175:105916.
PMID: 36336243
Personalized medicine intensifies interest in experimental paradigms that delineate sources of phenotypic variation. The paradigm of environmental enrichment allows for comparisons among differently housed laboratory rodents to unravel environmental effects...
5.
Senko A, Overall R, Silhavy J, Mlejnek P, Malinska H, Huttl M, et al.
PLoS Genet
. 2022 Apr;
18(4):e1009638.
PMID: 35377872
Neurogenesis in the adult hippocampus contributes to learning and memory in the healthy brain but is dysregulated in metabolic and neurodegenerative diseases. The molecular relationships between neural stem cell activity,...
6.
Leiter O, Zhuo Z, Rust R, Wasielewska J, Gronnert L, Kowal S, et al.
Cell Metab
. 2022 Feb;
34(3):408-423.e8.
PMID: 35120590
Although the neurogenesis-enhancing effects of exercise have been extensively studied, the molecular mechanisms underlying this response remain unclear. Here, we propose that this is mediated by the exercise-induced systemic release...
7.
Ostaszewski M, Niarakis A, Mazein A, Kuperstein I, Phair R, Orta-Resendiz A, et al.
Mol Syst Biol
. 2021 Dec;
17(12):e10851.
PMID: 34939300
No abstract available.
8.
Ostaszewski M, Niarakis A, Mazein A, Kuperstein I, Phair R, Orta-Resendiz A, et al.
Mol Syst Biol
. 2021 Oct;
17(10):e10387.
PMID: 34664389
We need to effectively combine the knowledge from surging literature with complex datasets to propose mechanistic models of SARS-CoV-2 infection, improving data interpretation and predicting key targets of intervention. Here,...
9.
Zocher S, Overall R, Berdugo-Vega G, Rund N, Karasinsky A, Adusumilli V, et al.
EMBO J
. 2021 Aug;
40(18):e107100.
PMID: 34337766
Adult neurogenesis enables the life-long addition of functional neurons to the hippocampus and is regulated by both cell-intrinsic molecular programs and behavioral activity. De novo DNA methylation is crucial for...
10.
Zocher S, Overall R, Lesche M, Dahl A, Kempermann G
Nat Commun
. 2021 Jun;
12(1):3892.
PMID: 34162876
The decline of brain function during aging is associated with epigenetic changes, including DNA methylation. Lifestyle interventions can improve brain function during aging, but their influence on age-related epigenetic changes...