Sara Zaccara
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Explore the profile of Sara Zaccara including associated specialties, affiliations and a list of published articles.
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18
Citations
3030
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Recent Articles
11.
Ries R, Zaccara S, Klein P, Olarerin-George A, Namkoong S, Pickering B, et al.
Nature
. 2019 Jul;
571(7765):424-428.
PMID: 31292544
N-methyladenosine (mA) is the most prevalent modified nucleotide in mRNA, with around 25% of mRNAs containing at least one mA. Methylation of mRNA to form mA is required for diverse...
12.
Boulias K, Toczydlowska-Socha D, Hawley B, Liberman N, Takashima K, Zaccara S, et al.
Mol Cell
. 2019 Jul;
75(3):631-643.e8.
PMID: 31279658
mRNAs are regulated by nucleotide modifications that influence their cellular fate. Two of the most abundant modified nucleotides are N-methyladenosine (mA), found within mRNAs, and N,2'-O-dimethyladenosine (mAm), which is found...
13.
Vu L, Pickering B, Cheng Y, Zaccara S, Nguyen D, Minuesa G, et al.
Nat Med
. 2017 Sep;
23(11):1369-1376.
PMID: 28920958
N-methyladenosine (mA) is an abundant nucleotide modification in mRNA that is required for the differentiation of mouse embryonic stem cells. However, it remains unknown whether the mA modification controls the...
14.
Andrysik Z, Galbraith M, Guarnieri A, Zaccara S, Sullivan K, Pandey A, et al.
Genome Res
. 2017 Sep;
27(10):1645-1657.
PMID: 28904012
The tumor suppressor TP53 is the most frequently mutated gene product in human cancer. Close to half of all solid tumors carry inactivating mutations in the gene, while in the...
15.
Tebaldi T, Zaccara S, Alessandrini F, Bisio A, Ciribilli Y, Inga A
BMC Genomics
. 2015 Jun;
16:464.
PMID: 26081755
Background: Many recent studies using ChIP-seq approaches cross-referenced to trascriptome data and also to potentially unbiased in vitro DNA binding selection experiments are detailing with increasing precision the p53-directed gene...
16.
Bisio A, Zamborszky J, Zaccara S, Lion M, Tebaldi T, Sharma V, et al.
Oncotarget
. 2014 Nov;
5(23):12111-25.
PMID: 25401416
The p53 and NFκB sequence-specific transcription factors play crucial roles in cell proliferation and survival with critical, even if typically opposite, effects on cancer progression. To investigate a possible crosstalk...
17.
Bustin S, Benes V, Garson J, Hellemans J, Huggett J, Kubista M, et al.
Nat Methods
. 2013 Nov;
10(11):1063-7.
PMID: 24173381
Two surveys of over 1,700 publications whose authors use quantitative real-time PCR (qPCR) reveal a lack of transparent and comprehensive reporting of essential technical information. Reporting standards are significantly improved...
18.
Pinzani P, Salvianti F, Zaccara S, Massi D, De Giorgi V, Pazzagli M, et al.
Clin Chim Acta
. 2011 Aug;
412(23-24):2141-5.
PMID: 21839068
DNA integrity in blood is an emerging biomarker in cancer. Here we report a real time PCR approach for the absolute quantification of four amplicons of 67, 180, 306 and...