Sara Simonelli
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Explore the profile of Sara Simonelli including associated specialties, affiliations and a list of published articles.
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28
Citations
431
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Recent Articles
1.
Hardfeldt J, Cariello M, Simonelli S, Ossoli A, Scialpi N, Piglionica M, et al.
Biochim Biophys Acta Mol Cell Biol Lipids
. 2021 Nov;
1867(2):159087.
PMID: 34813947
Cardiometabolic risk factors increase the risk of atherosclerotic cardiovascular disease (ASCVD), but whether these metabolic anomalies affect the anti-atherogenic function of reverse cholesterol transport (RCT) is not yet clearly known....
2.
Colombo G, Bianconi V, Bonomi A, Simonelli S, Amato M, Frigerio B, et al.
Biomedicines
. 2021 Apr;
9(3).
PMID: 33799675
The impact of cholesteryl ester transfer protein (CETP) on atherosclerosis is highly debated. This study aimed to investigate the associations between plasma CETP or CETP genotypes and carotid intima-media thickness...
3.
Ossoli A, Strazzella A, Rottoli D, Zanchi C, Locatelli M, Zoja C, et al.
Metabolism
. 2020 Dec;
116:154464.
PMID: 33309714
Objective: CER-001 is an HDL mimetic that has been tested in different pathological conditions, but never with LCAT deficiency. This study was designed to investigate whether the absence of LCAT...
4.
Pavanello C, Ossoli A, Turri M, Strazzella A, Simonelli S, Laurenzi T, et al.
J Pharmacol Exp Ther
. 2020 Sep;
375(3):463-468.
PMID: 32980814
Lecithin:cholesterol acyltransferase (LCAT) is a unique plasma enzyme able to esterify cholesterol, and it plays an important role in HDL maturation and promotion of reverse cholesterol transport. Familial LCAT deficiency...
5.
Baragetti A, Ossoli A, Strazzella A, Simonelli S, Baragetti I, Grigore L, et al.
J Clin Med
. 2020 Jul;
9(7).
PMID: 32708515
Low high-density lipoprotein-cholesterol (HDL-c) is the most remarkable lipid trait both in mild-to-moderate chronic kidney disease (CKD) patients as well as in advanced renal disease stages, and we have previously...
6.
Dal Magro R, Simonelli S, Cox A, Formicola B, Corti R, Cassina V, et al.
Front Neurosci
. 2019 Jun;
13:419.
PMID: 31156358
Much evidence suggests a protective role of high-density lipoprotein (HDL) and its major apolipoprotein apoA-I, in Alzheimer's disease (AD). The biogenesis of nascent HDL derived from a first lipidation of...
7.
Ossoli A, Simonelli S, Varrenti M, Morici N, Oliva F, Stucchi M, et al.
Arterioscler Thromb Vasc Biol
. 2019 Mar;
39(5):915-924.
PMID: 30894011
Objective- Aim of this study was to evaluate changes in LCAT (lecithin:cholesterol acyltransferase) concentration and activity in patients with an acute coronary syndrome, to investigate if these changes are related...
8.
Manzini S, Busnelli M, Parolini C, Minoli L, Ossoli A, Brambilla E, et al.
Pharmacol Res
. 2018 Dec;
141:189-200.
PMID: 30593851
Topiramate is an anticonvulsant drug also prescribed for migraine prophylaxis that acts through several mechanisms of action. Several studies indicate that topiramate induces weight loss and a moderate reduction of...
9.
Simonelli S, Ossoli A, Banfi C, Pavanello C, Calabresi L, Gianazza E
J Proteomics
. 2018 Dec;
198:113-118.
PMID: 30529744
Genetic LCAT deficiency is a rare recessive autosomal disease due to loss-of-function mutations in the gene coding for the enzyme lecithin:cholesterol acyltransferase (LCAT). Homozygous carriers are characterized by corneal opacity,...
10.
Hanna E, Simonelli S, Chamney S, Ossoli A, Mullan R
J Clin Lipidol
. 2018 Sep;
12(5):1151-1156.
PMID: 30201532
A 29-year-old lady was diagnosed with lecithin:cholesterol acyltransferase (LCAT) deficiency having presented with bilateral corneal clouding, severely reduced high density lipoproteins cholesterol, and proteinuria. She is a compound heterozygote with...