Sara Schad
Overview
Explore the profile of Sara Schad including associated specialties, affiliations and a list of published articles.
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Snapshot
Articles
5
Citations
451
Followers
0
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Related Specialties
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Recent Articles
1.
Hirschhorn D, Budhu S, Kraehenbuehl L, Gigoux M, Schroder D, Chow A, et al.
Cell
. 2023 Mar;
186(7):1432-1447.e17.
PMID: 37001503
Cancer immunotherapies, including adoptive T cell transfer, can be ineffective because tumors evolve to display antigen-loss-variant clones. Therapies that activate multiple branches of the immune system may eliminate escape variants....
2.
Gigoux M, Holmstrom M, Zappasodi R, Park J, Pourpe S, Bozkus C, et al.
Sci Transl Med
. 2022 Jun;
14(649):eaba4380.
PMID: 35704596
The majority of JAK2-negative myeloproliferative neoplasms (MPNs) have disease-initiating frameshift mutations in calreticulin (), resulting in a common carboxyl-terminal mutant fragment (CALR), representing an attractive source of neoantigens for cancer...
3.
Chow A, Schad S, Green M, Hellmann M, Allaj V, Ceglia N, et al.
Cancer Cell
. 2021 Jun;
39(7):973-988.e9.
PMID: 34115989
Immune checkpoint blockade (ICB) has been a remarkable clinical advance for cancer; however, the majority of patients do not respond to ICB therapy. We show that metastatic disease in the...
4.
Budhu S, Giese R, Gupta A, Fitzgerald K, Zappasodi R, Schad S, et al.
Cell Rep
. 2021 Jan;
34(2):108620.
PMID: 33440157
Phosphatidylserine (PS) is exposed on the surface of apoptotic cells and is known to promote immunosuppressive signals in the tumor microenvironment (TME). Antibodies that block PS interaction with its receptors...
5.
Guerriero J, Sotayo A, Ponichtera H, Castrillon J, Pourzia A, Schad S, et al.
Nature
. 2017 Mar;
543(7645):428-432.
PMID: 28273064
Although the main focus of immuno-oncology has been manipulating the adaptive immune system, harnessing both the innate and adaptive arms of the immune system might produce superior tumour reduction and...