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Sara Poletti

Explore the profile of Sara Poletti including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 121
Citations 2610
Followers 0
Related Specialties
Psychiatry
Neurology
Pharmacology
Top 10 Co-Authors
Francesco Benedetti
Cristina Colombo
Benedetta Vai
Cristina Lorenzi
Irene Bollettini
Enrico Smeraldi
Clara Locatelli
Raffaella Zanardi
Daniele Radaelli
Andrea Falini
Published In
J Affect Disord
Eur Neuropsychopharmacol
Psychiatry Res
Brain Behav Immun
Prog Neuropsychopharmacol Biol Psychiatry
Affiliations
Soon will be listed here.
Recent Articles
1.
Cardiovascular Risk Predicts White Matter Hyperintensities, Brain Atrophy and Treatment Resistance in Major Depressive Disorder: Role of Genetic Liability
Paolini M, Maccario M, Saredi V, Verri A, Calesella F, Raffaelli L, et al.
Acta Psychiatr Scand . 2025 Feb; PMID: 40014927
Introduction: Depressive disorders are a leading cause of global disease burden, particularly with the challenge of treatment-resistant depression (TRD). Research points to a complex bidirectional relationship between cardiovascular (CV) risk...
2.
Classification of Major Depressive Disorder Using Vertex-Wise Brain Sulcal Depth, Curvature, and Thickness with a Deep and a Shallow Learning Model
Goya-Maldonado R, Erwin-Grabner T, Zeng L, Ching C, Aleman A, Amod A, et al.
ArXiv . 2025 Feb; PMID: 39975425
Major depressive disorder (MDD) is a complex psychiatric disorder that affects the lives of hundreds of millions of individuals around the globe. Even today, researchers debate if morphological alterations in...
3.
Effects of kynurenine pathway metabolites on choroid plexus volume, hemodynamic response, and spontaneous neural activity: A new mechanism for disrupted neurovascular communication and impaired cognition in mood disorders
Beatrice B, Bravi B, Verga C, Chiara V, Palladini M, Mariagrazia P, et al.
Brain Behav Immun . 2025 Feb; 125:414-427. PMID: 39909168
Major Depressive Disorder (MDD) and Bipolar Disorder (BD) involve alterations of immune-inflammatory setpoints that activate the kynurenine pathway (KP), affecting serotoninergic and glutamatergic neurotransmission through indoleamine-2,3-dioxygenase (IDO) activity. This process...
4.
Abnormally slow dynamics in occipital cortex of depression
Scalabrini A, Poletti S, Vai B, Paolini M, Gao Y, Hu Y, et al.
J Affect Disord . 2025 Jan; 374:523-530. PMID: 39818334
Aim: Major depressive disorder (MDD) is characterized by altered activity in various higher-order regions like the anterior cingulate and prefrontal cortex. While some findings also show changes in lower-order sensory...
5.
Transdiagnostic alterations in white matter microstructure associated with suicidal thoughts and behaviours in the ENIGMA Suicidal Thoughts and Behaviours consortium
van Velzen L, Colic L, Ceja Z, Dauvermann M, Villa L, Savage H, et al.
medRxiv . 2025 Jan; PMID: 39802789
Previous studies have suggested that alterations in white matter (WM) microstructure are implicated in suicidal thoughts and behaviours (STBs). However, findings of diffusion tensor imaging (DTI) studies have been inconsistent....
6.
Disentangling the Genetic Landscape of Peripartum Depression: A Multi-Polygenic Machine Learning Approach on an Italian Sample
Harrington Y, Fortaner-Uya L, Paolini M, Poletti S, Lorenzi C, Spadini S, et al.
Genes (Basel) . 2025 Jan; 15(12. PMID: 39766785
Background: The genetic determinants of peripartum depression (PPD) are not fully understood. Using a multi-polygenic score approach, we characterized the relationship between genome-wide information and the history of PPD in...
7.
Predicting Antidepressant Treatment Response From Cortical Structure on MRI: A Mega-Analysis From the ENIGMA-MDD Working Group
Poirot M, Boucherie D, Caan M, Goya-Maldonado R, Belov V, Corruble E, et al.
Hum Brain Mapp . 2025 Jan; 46(1):e70053. PMID: 39757979
Accurately predicting individual antidepressant treatment response could expedite the lengthy trial-and-error process of finding an effective treatment for major depressive disorder (MDD). We tested and compared machine learning-based methods that...
8.
Conventional and new immunotherapies for immune system dysregulation in postpartum mood disorders: comparisons to immune system dysregulations in bipolar disorder, major depression, and postpartum autoimmune thyroid disease
Drexhage H, Bergink V, Poletti S, Benedetti F, Osborne L
Expert Rev Clin Immunol . 2024 Oct; 21(2):113-135. PMID: 39441185
Introduction: Postpartum mood disorders are heterogenous disorders and comprise postpartum psychosis and postpartum depression. Evidence is accumulating that systemic monocyte/macrophage activation, low-grade inflammation and (premature senescence related) T cell defects...
9.
History of Peripartum Depression Moderates the Association Between Estradiol Polygenic Risk Scores and Basal Ganglia Volumes in Major Depressive Disorder
Harrington Y, Paolini M, Fortaner-Uya L, Maccario M, Melloni E, Poletti S, et al.
Biol Psychiatry Cogn Neurosci Neuroimaging . 2024 Oct; 10(1):7-16. PMID: 39362408
Background: The neurobiological differences between women who have experienced a peripartum episode and those who have only had episodes outside of this period are not well understood. Methods: Sixty-four parous...
10.
Multimodal brain-derived subtypes of Major depressive disorder differentiate patients for anergic symptoms, immune-inflammatory markers, history of childhood trauma and treatment-resistance
Colombo F, Calesella F, Bravi B, Fortaner-Uya L, Monopoli C, Tassi E, et al.
Eur Neuropsychopharmacol . 2024 Jun; 85:45-57. PMID: 38936143
An estimated 30 % of Major Depressive Disorder (MDD) patients exhibit resistance to conventional antidepressant treatments. Identifying reliable biomarkers of treatment-resistant depression (TRD) represents a major goal of precision psychiatry,...