Alpha 2.0
Login Register
» Authors » Francesco Benedetti

Francesco Benedetti

Explore the profile of Francesco Benedetti including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 280
Citations 6821
Followers 0
Related Specialties
Psychiatry
Neurology
Pharmacology
Top 10 Co-Authors
Sara Poletti
Cristina Colombo
Enrico Smeraldi
Sara Dallaspezia
Benedetta Vai
Cristina Lorenzi
Irene Bollettini
Dan J Stein
Clara Locatelli
Paul M Thompson
Published In
J Affect Disord
Eur Neuropsychopharmacol
Psychiatry Res
Prog Neuropsychopharmacol Biol Psychiatry
Bipolar Disord
Affiliations
Soon will be listed here.
Recent Articles
1.
Cardiovascular Risk Predicts White Matter Hyperintensities, Brain Atrophy and Treatment Resistance in Major Depressive Disorder: Role of Genetic Liability
Paolini M, Maccario M, Saredi V, Verri A, Calesella F, Raffaelli L, et al.
Acta Psychiatr Scand . 2025 Feb; PMID: 40014927
Introduction: Depressive disorders are a leading cause of global disease burden, particularly with the challenge of treatment-resistant depression (TRD). Research points to a complex bidirectional relationship between cardiovascular (CV) risk...
2.
Classification of Major Depressive Disorder Using Vertex-Wise Brain Sulcal Depth, Curvature, and Thickness with a Deep and a Shallow Learning Model
Goya-Maldonado R, Erwin-Grabner T, Zeng L, Ching C, Aleman A, Amod A, et al.
ArXiv . 2025 Feb; PMID: 39975425
Major depressive disorder (MDD) is a complex psychiatric disorder that affects the lives of hundreds of millions of individuals around the globe. Even today, researchers debate if morphological alterations in...
3.
Effects of kynurenine pathway metabolites on choroid plexus volume, hemodynamic response, and spontaneous neural activity: A new mechanism for disrupted neurovascular communication and impaired cognition in mood disorders
Beatrice B, Bravi B, Verga C, Chiara V, Palladini M, Mariagrazia P, et al.
Brain Behav Immun . 2025 Feb; 125:414-427. PMID: 39909168
Major Depressive Disorder (MDD) and Bipolar Disorder (BD) involve alterations of immune-inflammatory setpoints that activate the kynurenine pathway (KP), affecting serotoninergic and glutamatergic neurotransmission through indoleamine-2,3-dioxygenase (IDO) activity. This process...
4.
Chronobiologic treatments for mood disorders
Dallaspezia S, Benedetti F
Handb Clin Neurol . 2025 Jan; 206():181-192. PMID: 39864926
Chronotherapeutics are nonpharmacologic interventions whose development stems from investigations into sleep and circadian rhythm abnormalities associated with mood disorder. These therapies utilize controlled exposure to environmental cues (light, darkness) to...
5.
Specific symptomatology profile associated with treatment resistant depression: A multicentric study from the Group for the Study of Resistant Depression with a focus on sex
Luca M, Luca A, Messina A, Bartova L, Kasper S, Zohar J, et al.
J Affect Disord . 2025 Jan; 375:249-255. PMID: 39862984
Background: Clinical predictors of treatment-resistant depression could improve treatment strategies. Depressive symptom profiles at baseline are potential outcome predictors, but little evidence is available, and sex-specific profiles have been scarcely...
6.
A generalizable normative deep autoencoder for brain morphological anomaly detection: application to the multi-site StratiBip dataset on bipolar disorder in an external validation framework
Sampaio I, Tassi E, Bellani M, Benedetti F, Nenadic I, Phillips M, et al.
Artif Intell Med . 2025 Jan; 161:103063. PMID: 39837135
The heterogeneity of psychiatric disorders makes researching disorder-specific neurobiological markers an ill-posed problem. Here, we face the need for disease stratification models by presenting a generalizable multivariate normative modelling framework...
7.
Abnormally slow dynamics in occipital cortex of depression
Scalabrini A, Poletti S, Vai B, Paolini M, Gao Y, Hu Y, et al.
J Affect Disord . 2025 Jan; 374:523-530. PMID: 39818334
Aim: Major depressive disorder (MDD) is characterized by altered activity in various higher-order regions like the anterior cingulate and prefrontal cortex. While some findings also show changes in lower-order sensory...
8.
Transdiagnostic alterations in white matter microstructure associated with suicidal thoughts and behaviours in the ENIGMA Suicidal Thoughts and Behaviours consortium
van Velzen L, Colic L, Ceja Z, Dauvermann M, Villa L, Savage H, et al.
medRxiv . 2025 Jan; PMID: 39802789
Previous studies have suggested that alterations in white matter (WM) microstructure are implicated in suicidal thoughts and behaviours (STBs). However, findings of diffusion tensor imaging (DTI) studies have been inconsistent....
9.
Disentangling the Genetic Landscape of Peripartum Depression: A Multi-Polygenic Machine Learning Approach on an Italian Sample
Harrington Y, Fortaner-Uya L, Paolini M, Poletti S, Lorenzi C, Spadini S, et al.
Genes (Basel) . 2025 Jan; 15(12. PMID: 39766785
Background: The genetic determinants of peripartum depression (PPD) are not fully understood. Using a multi-polygenic score approach, we characterized the relationship between genome-wide information and the history of PPD in...
10.
Predicting Antidepressant Treatment Response From Cortical Structure on MRI: A Mega-Analysis From the ENIGMA-MDD Working Group
Poirot M, Boucherie D, Caan M, Goya-Maldonado R, Belov V, Corruble E, et al.
Hum Brain Mapp . 2025 Jan; 46(1):e70053. PMID: 39757979
Accurately predicting individual antidepressant treatment response could expedite the lengthy trial-and-error process of finding an effective treatment for major depressive disorder (MDD). We tested and compared machine learning-based methods that...