Sara Noorani
Overview
Explore the profile of Sara Noorani including associated specialties, affiliations and a list of published articles.
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6
Citations
38
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Recent Articles
1.
Ana G, Malebari A, Noorani S, Fayne D, OBoyle N, Zisterer D, et al.
Pharmaceuticals (Basel)
. 2025 Jan;
18(1).
PMID: 39861179
The synthesis of ()-1-(1,3-diphenylallyl)-1-1,2,4-triazoles and related compounds as anti-mitotic agents with activity in breast cancer was investigated. These compounds were designed as hybrids of the microtubule-targeting chalcones, indanones, and the...
2.
Byrne A, Bright S, McKeown J, Bergin A, Twamley B, McElligott A, et al.
Molecules
. 2023 Dec;
28(24).
PMID: 38138584
Chronic lymphocytic leukaemia (CLL) is a malignancy of the immune B lymphocyte cells and is the most common leukaemia diagnosed in developed countries. In this paper, we report the synthesis...
3.
Curley R, Burke C, Gkika K, Noorani S, Walsh N, Keyes T
Inorg Chem
. 2023 Aug;
62(32):13089-13102.
PMID: 37535942
Tridentate ligand-coordinated ruthenium (II) polypyridyl complexes with large N-Ru-N bite angles have been shown to promote ligand field splitting and reduce singlet-triplet state mixing leading to dramatically extended emission quantum...
4.
Gkika K, Noorani S, Walsh N, Keyes T
Inorg Chem
. 2021 May;
60(11):8123-8134.
PMID: 33978399
The preparation of two polyarginine conjugates of the complex Os(II) [bis-(4'-(4-carboxyphenyl)-2,2':6',2″-terpyridine)] [Os-(R)] ( = 4 and 8; = 10 and 18) is reported, to explore whether the R8 peptide sequence...
5.
Ana G, Kelly P, Malebari A, Noorani S, Nathwani S, Twamley B, et al.
Pharmaceuticals (Basel)
. 2021 Mar;
14(2).
PMID: 33671674
We report the synthesis and biochemical evaluation of compounds that are designed as hybrids of the microtubule targeting benzophenone phenstatin and the aromatase inhibitor letrozole. A preliminary screening in estrogen...
6.
Malebari A, Fayne D, Nathwani S, OConnell F, Noorani S, Twamley B, et al.
Eur J Med Chem
. 2020 Jan;
189:112050.
PMID: 31954879
A series of novel 1,4-diaryl-2-azetidinone analogues of combretastatin A-4 (CA-4) have been designed, synthesised and evaluated in vitro for antiproliferative activity, antiapoptotic activity and inhibition of tubulin polymerisation. Glucuronidation of...
7.
OBoyle N, Ana G, Kelly P, Nathwani S, Noorani S, Fayne D, et al.
Org Biomol Chem
. 2019 Jun;
17(25):6184-6200.
PMID: 31173031
Microtubules are a validated clinical target for the treatment of many cancers. We describe the design, synthesis, biochemical evaluation, and molecular modelling studies of a series of analogues of the...