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Sara E Chasnoff

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Articles 6
Citations 170
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Recent Articles
1.
Iglesia M, Jayasinghe R, Chen S, Terekhanova N, Herndon J, Storrs E, et al.
Nat Cancer . 2024 Oct; 5(11):1713-1736. PMID: 39478117
Breast cancer (BC) is defined by distinct molecular subtypes with different cells of origin. The transcriptional networks that characterize the subtype-specific tumor-normal lineages are not established. In this work, we...
2.
Iglesia M, Jayasinghe R, Chen S, Terekhanova N, Herndon J, Storrs E, et al.
bioRxiv . 2023 Nov; PMID: 37961519
Breast cancer is a heterogeneous disease, and treatment is guided by biomarker profiles representing distinct molecular subtypes. Breast cancer arises from the breast ductal epithelium, and experimental data suggests breast...
3.
Terekhanova N, Karpova A, Liang W, Strzalkowski A, Chen S, Li Y, et al.
Nature . 2023 Nov; 623(7986):432-441. PMID: 37914932
Chromatin accessibility is essential in regulating gene expression and cellular identity, and alterations in accessibility have been implicated in driving cancer initiation, progression and metastasis. Although the genetic contributions to...
4.
Zhou D, Jayasinghe R, Chen S, Herndon J, Iglesia M, Navale P, et al.
Nat Genet . 2022 Aug; 54(9):1390-1405. PMID: 35995947
Pancreatic ductal adenocarcinoma is a lethal disease with limited treatment options and poor survival. We studied 83 spatial samples from 31 patients (11 treatment-naïve and 20 treated) using single-cell/nucleus RNA...
5.
Druley T, Wang L, Lin S, Lee J, Zhang Q, Daw E, et al.
BMC Geriatr . 2016 Apr; 16:80. PMID: 27060904
Background: The Long Life Family Study (LLFS) is an international study to identify the genetic components of various healthy aging phenotypes. We hypothesized that pedigree-specific rare variants at longevity-associated genes...
6.
Kokubo T, Ishikawa N, Uchida H, Chasnoff S, Xie X, Mathew S, et al.
J Am Soc Nephrol . 2009 May; 20(6):1236-45. PMID: 19423694
Arteriovenous (AV) access failure resulting from venous neointimal hyperplasia is a major cause of morbidity in patients with ESRD. To understand the role of chronic kidney disease (CKD) in the...