Nataly Naser Al Deen
Overview
Explore the profile of Nataly Naser Al Deen including associated specialties, affiliations and a list of published articles.
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16
Citations
214
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Recent Articles
1.
Iglesia M, Jayasinghe R, Chen S, Terekhanova N, Herndon J, Storrs E, et al.
Nat Cancer
. 2024 Oct;
5(11):1713-1736.
PMID: 39478117
Breast cancer (BC) is defined by distinct molecular subtypes with different cells of origin. The transcriptional networks that characterize the subtype-specific tumor-normal lineages are not established. In this work, we...
2.
Liu J, Cao S, Imbach K, Gritsenko M, Lih T, Kyle J, et al.
Cancer Cell
. 2024 Jul;
42(7):1217-1238.e19.
PMID: 38981438
Although genomic anomalies in glioblastoma (GBM) have been well studied for over a decade, its 5-year survival rate remains lower than 5%. We seek to expand the molecular landscape of...
3.
Li G, Chen L, Hsiao Y, Mannan R, Zhang Y, Luo J, et al.
Cell Rep Med
. 2024 May;
5(5):101547.
PMID: 38703764
Non-clear cell renal cell carcinomas (non-ccRCCs) encompass diverse malignant and benign tumors. Refinement of differential diagnosis biomarkers, markers for early prognosis of aggressive disease, and therapeutic targets to complement immunotherapy...
4.
Iglesia M, Jayasinghe R, Chen S, Terekhanova N, Herndon J, Storrs E, et al.
bioRxiv
. 2023 Nov;
PMID: 37961519
Breast cancer is a heterogeneous disease, and treatment is guided by biomarker profiles representing distinct molecular subtypes. Breast cancer arises from the breast ductal epithelium, and experimental data suggests breast...
5.
Terekhanova N, Karpova A, Liang W, Strzalkowski A, Chen S, Li Y, et al.
Nature
. 2023 Nov;
623(7986):432-441.
PMID: 37914932
Chromatin accessibility is essential in regulating gene expression and cellular identity, and alterations in accessibility have been implicated in driving cancer initiation, progression and metastasis. Although the genetic contributions to...
6.
Wu Y, Terekhanova N, Caravan W, Naser Al Deen N, Lal P, Chen S, et al.
Nat Commun
. 2023 May;
14(1):2817.
PMID: 37198186
No abstract available.
7.
Wu Y, Terekhanova N, Caravan W, Naser Al Deen N, Lal P, Chen S, et al.
Nat Commun
. 2023 Mar;
14(1):1681.
PMID: 36973268
Identifying tumor-cell-specific markers and elucidating their epigenetic regulation and spatial heterogeneity provides mechanistic insights into cancer etiology. Here, we perform snRNA-seq and snATAC-seq in 34 and 28 human clear cell...
8.
Li Y, Lih T, Dhanasekaran S, Mannan R, Chen L, Cieslik M, et al.
Cancer Cell
. 2022 Dec;
41(1):139-163.e17.
PMID: 36563681
Clear cell renal cell carcinomas (ccRCCs) represent ∼75% of RCC cases and account for most RCC-associated deaths. Inter- and intratumoral heterogeneity (ITH) results in varying prognosis and treatment outcomes. To...
9.
Naser Al Deen N, Lanman N, Chittiboyina S, Fostok S, Nasr R, Lelievre S, et al.
Sci Rep
. 2022 Dec;
12(1):21974.
PMID: 36539576
microRNAs (miRNAs) serve as novel noninvasive cancer biomarkers. In an HMT-3522 S1 (S1) breast epithelial risk-progression three-dimensional (3D) culture model, non-neoplastic S1 cells form a fully polarized epithelium. When silenced...
10.
Zhou D, Jayasinghe R, Chen S, Herndon J, Iglesia M, Navale P, et al.
Nat Genet
. 2022 Aug;
54(9):1390-1405.
PMID: 35995947
Pancreatic ductal adenocarcinoma is a lethal disease with limited treatment options and poor survival. We studied 83 spatial samples from 31 patients (11 treatment-naïve and 20 treated) using single-cell/nucleus RNA...