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Sankalp Malhotra

Explore the profile of Sankalp Malhotra including associated specialties, affiliations and a list of published articles. Areas
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Articles 7
Citations 378
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Recent Articles
1.
Malhotra S, Yang C, Nicholson K, Wozniak D, Hayes Jr D
Lung . 2024 Aug; 202(5):711-722. PMID: 39096413
Purpose: Pseudomonas aeruginosa is the predominant bacterial pathogen colonizing the cystic fibrosis (CF) lung. Mixed populations of nonmucoid and mucoid variants of P. aeruginosa have been isolated from the CF...
2.
Malhotra S, Hyer J, Dalmacy D, Hayes Jr D, Tumin D, Kirkby S, et al.
J Cyst Fibros . 2024 Jan; 23(2):314-320. PMID: 38220475
Background: As the life expectancy of the cystic fibrosis (CF) population is lengthening with modulator therapies, diligent age-appropriate screening and preventive care are increasingly vital for long-term health and wellbeing....
3.
Malhotra S, Hayes Jr D, Wozniak D
Clin Microbiol Rev . 2019 May; 32(3). PMID: 31142499
In human pathophysiology, the clash between microbial infection and host immunity contributes to multiple diseases. Cystic fibrosis (CF) is a classical example of this phenomenon, wherein a dysfunctional, hyperinflammatory immune...
4.
Malhotra S, Hayes Jr D, Wozniak D
J Cyst Fibros . 2019 May; 18(6):796-803. PMID: 31036488
Background: Pseudomonas aeruginosa is the prominent bacterial pathogen in the cystic fibrosis (CF) lung and contributes to significant morbidity and mortality. Though P. aeruginosa strains initially colonizing the CF lung...
5.
Malhotra S, Limoli D, English A, Parsek M, Wozniak D
mBio . 2018 Mar; 9(2). PMID: 29588399
causes chronic pulmonary infections in patients with cystic fibrosis (CF). mucoid conversion, defined by overproduction of the exopolysaccharide alginate, correlates with accelerated decline in CF patient lung function. Recalcitrance of...
6.
Brockson M, Novotny L, Mokrzan E, Malhotra S, Jurcisek J, Akbar R, et al.
Mol Microbiol . 2014 Jul; 93(6):1246-58. PMID: 25069521
The extracellular polymeric substance produced by many human pathogens during biofilm formation often contains extracellular DNA (eDNA). Strands of bacterial eDNA within the biofilm matrix can occur in a lattice-like...
7.
Abdulrahman B, Abu Khweek A, Akhter A, Caution K, Tazi M, Hassan H, et al.
J Biol Chem . 2012 Nov; 288(3):2049-58. PMID: 23148214
Cystic fibrosis is the most common inherited lethal disease in Caucasians. It is caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR), of which the cftr ΔF508 mutation...