Sanjivan Gautam
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Explore the profile of Sanjivan Gautam including associated specialties, affiliations and a list of published articles.
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11
Citations
717
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Recent Articles
1.
Gautam S, Gautam B, Shilpakar R, K C S, Kurmi O
J Immunother Cancer
. 2025 Jan;
12(12.
PMID: 39794933
Low- and middle-income countries (LMICs) face a significant burden of cancer prevalence and incidence. However, the survival rates for patients with cancer in these regions are notably lower than those...
2.
Kurmi O, Chaudhary N, Delanerolle G, Bolton C, Pant P, Regmi P, et al.
BMJ Open
. 2024 Nov;
14(11):e088896.
PMID: 39521464
Introduction: The Nepal Family Cohort study uses a life course epidemiological approach to collect comprehensive data on children's and their parents' environmental, behavioural and metabolic risk factors. These factors can...
3.
Baldwin J, Heuser-Loy C, Saha T, Schelker R, Slavkovic-Lukic D, Strieder N, et al.
Cell
. 2024 Sep;
187(23):6614-6630.e21.
PMID: 39276774
Mitochondrial loss and dysfunction drive T cell exhaustion, representing major barriers to successful T cell-based immunotherapies. Here, we describe an innovative platform to supply exogenous mitochondria to T cells, overcoming...
4.
Hermans D, Gautam S, Garcia-Canaveras J, Gromer D, Mitra S, Spolski R, et al.
Proc Natl Acad Sci U S A
. 2020 Mar;
117(11):6047-6055.
PMID: 32123114
Interleukin (IL)-2 and IL-21 dichotomously shape CD8 T cell differentiation. IL-2 drives terminal differentiation, generating cells that are poorly effective against tumors, whereas IL-21 promotes stem cell memory T cells...
5.
Ji Y, Fioravanti J, Zhu W, Wang H, Wu T, Hu J, et al.
Nat Commun
. 2019 May;
10(1):2157.
PMID: 31089138
T cell senescence and exhaustion are major barriers to successful cancer immunotherapy. Here we show that miR-155 increases CD8 T cell antitumor function by restraining T cell senescence and functional...
6.
Gautam S, Fioravanti J, Zhu W, Le Gall J, Brohawn P, Lacey N, et al.
Nat Immunol
. 2019 Feb;
20(3):337-349.
PMID: 30778251
Stem cells are maintained by transcriptional programs that promote self-renewal and repress differentiation. Here, we found that the transcription factor c-Myb was essential for generating and maintaining stem cells in...
7.
Pilipow K, Scamardella E, Puccio S, Gautam S, De Paoli F, Mazza E, et al.
JCI Insight
. 2018 Sep;
3(18).
PMID: 30232291
Adoptive T cell transfer (ACT) immunotherapy benefits from early differentiated stem cell memory T (Tscm) cells capable of persisting in the long term and generating potent antitumor effectors. Due to...
8.
Wiesmeier M, Gautam S, Kirschnek S, Hacker G
PLoS One
. 2016 Dec;
11(12):e0168055.
PMID: 27942017
Severe congenital neutropenia (SCN) is characterised by a differentiation block in the bone marrow and low neutrophil numbers in the peripheral blood, which correlates with increased risk of bacterial infections....
9.
Sabatino M, Hu J, Sommariva M, Gautam S, Fellowes V, Hocker J, et al.
Blood
. 2016 May;
128(4):519-28.
PMID: 27226436
Long-lived, self-renewing, multipotent T memory stem cells (TSCM) can trigger profound and sustained tumor regression but their rareness poses a major hurdle to their clinical application. Presently, clinically compliant procedures...
10.
Ji Y, Wrzesinski C, Yu Z, Hu J, Gautam S, Hawk N, et al.
Proc Natl Acad Sci U S A
. 2014 Dec;
112(2):476-81.
PMID: 25548153
Lymphodepleting regimens are used before adoptive immunotherapy to augment the antitumor efficacy of transferred T cells by removing endogenous homeostatic "cytokine sinks." These conditioning modalities, however, are often associated with...