Sang Mi Shim
Overview
Explore the profile of Sang Mi Shim including associated specialties, affiliations and a list of published articles.
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Articles
14
Citations
505
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0
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Recent Articles
1.
Shim S, Choi H, Kwon S, Kim H, Sung K, Jung E, et al.
Autophagy
. 2022 Oct;
19(6):1642-1661.
PMID: 36184612
In the N-degron pathway, N-recognins recognize cognate substrates for degradation via the ubiquitin (Ub)-proteasome system (UPS) or the autophagy-lysosome system (hereafter autophagy). We have recently shown that the autophagy receptor...
2.
Lee Y, Kim J, Jung C, Kim Y, Jung E, Lee S, et al.
Autophagy
. 2022 Mar;
18(12):2926-2945.
PMID: 35316156
The N-degron pathway is a proteolytic system in which the N-terminal degrons (N-degrons) of proteins, such as arginine (Nt-Arg), induce the degradation of proteins and subcellular organelles via the ubiquitin-proteasome...
3.
Kang J, Kim D, Sung K, Shim S, Cha-Molstad H, Soung N, et al.
Cancers (Basel)
. 2021 Mar;
13(4).
PMID: 33670717
Cancer-associated fibroblasts (CAFs) are important in tumor progression. The autophagy adaptor protein, p62/SQSTM1/Sequestosome-1, is up-regulated in tumors, but down-regulated in CAFs in the early stages of lung adenocarcinoma. We investigated...
4.
Lee D, Kim D, Kim S, Jeong S, Kim J, Shim S, et al.
Autophagy
. 2018 Jul;
14(11):1870-1885.
PMID: 29976090
Macroautophagy is induced under various stresses to remove cytotoxic materials, including misfolded proteins and their aggregates. These protein cargoes are collected by specific autophagic receptors such as SQSTM1/p62 (sequestosome 1)...
5.
Shim S, Choi H, Sung K, Lee Y, Kim S, Kim D, et al.
Sci Signal
. 2018 Jan;
11(511).
PMID: 29295953
BiP and other endoplasmic reticulum (ER)-resident proteins are thought to be metabolically stable and to function primarily in the ER lumen. We sought to assess how the abundance of these...
6.
Cha-Molstad H, Lee S, Kim J, Sung K, Hwang J, Shim S, et al.
Autophagy
. 2017 Dec;
14(2):359-361.
PMID: 29261001
In macroautophagy/autophagy, cargoes are collected by specific receptors, such as SQSTM1/p62 (sequestosome 1), and delivered to phagophores for lysosomal degradation. To date, little is known about how cells modulate SQSTM1...
7.
Cha-Molstad H, Yu J, Feng Z, Lee S, Kim J, Yang P, et al.
Nat Commun
. 2017 Jul;
8(1):102.
PMID: 28740232
Macroautophagy mediates the selective degradation of proteins and non-proteinaceous cellular constituents. Here, we show that the N-end rule pathway modulates macroautophagy. In this mechanism, the autophagic adapter p62/SQSTM1/Sequestosome-1 is an...
8.
Lee H, Ahn H, Lee W, Oh Y, Choi H, Shim S, et al.
Mol Neurobiol
. 2015 Dec;
53(10):6620-6634.
PMID: 26637326
Huntington's disease (HD) is a devastating neurodegenerative disorder, which is caused by the expression and aggregation of polyQ-expanded mutant huntingtin protein (mtHTT). While toxic mtHTT aggregates are primarily eliminated through...
9.
Kim D, Lee D, Chang E, Kim J, Hwang J, Kim J, et al.
Stem Cells Dev
. 2015 Jul;
24(20):2378-90.
PMID: 26154268
Our previous studies demonstrated that transplantation of human umbilical cord blood-derived mesenchymal stem cells (hUCB-MSCs) into the hippocampus of a transgenic mouse model of Alzheimer's disease (AD) reduced amyloid-β (Aβ)...
10.
Shim S, Lee W, Kim Y, Chang J, Song S, Jung Y
Cell Rep
. 2012 Aug;
2(3):603-15.
PMID: 22921402
The ubiquitin-proteasome system is essential for maintaining protein homeostasis. However, proteasome dysregulation in chronic diseases is poorly understood. Through genome-wide cell-based screening using 5,500 cDNAs, a signaling pathway leading to...