Sang-Hoon Sin
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Explore the profile of Sang-Hoon Sin including associated specialties, affiliations and a list of published articles.
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Recent Articles
11.
Sin S, Dittmer D
Blood
. 2013 Feb;
121(15):2952-63.
PMID: 23365457
Kaposi sarcoma (KS) is associated with KS-associated herpesvirus (KSHV). This virus also causes B-cell lymphoma and B-cell hyperplasia. There exists no in vivo model for KSHV-associated B-cell malignancies or premalignant...
12.
Chen W, Sin S, Wen K, Damania B, Dittmer D
PLoS Pathog
. 2012 Dec;
8(11):e1003048.
PMID: 23209418
Heat-shock protein 90 (Hsp90) inhibitors exhibit activity against human cancers. We evaluated a series of new, oral bioavailable, chemically diverse Hsp90 inhibitors (PU-H71, AUY922, BIIB021, NVP-BEP800) against Kaposi sarcoma (KS)....
13.
Tamburro K, Yang D, Poisson J, Fedoriw Y, Roy D, Lucas A, et al.
Virology
. 2012 Aug;
433(1):220-5.
PMID: 22925337
KSHV inflammatory cytokine syndrome (KICS) is a newly described condition characterized by systemic illness as a result of systemic, lytic KSHV infection. We used Illumina sequencing to establish the DNA...
14.
Sin S, Dittmer D
J Interferon Cytokine Res
. 2011 Dec;
32(2):53-9.
PMID: 22142220
Gammaherpesviruses such as Epstein-Barr virus (EBV, human herpesvirus 4) and Kaposi sarcoma-associated herpesvirus (KSHV, human herpesvirus 8) establish lifelong infection in the host. To further this lifestyle, they encode homologs...
15.
Ramos J, Sin S, Staudt M, Roy D, Vahrson W, Dezube B, et al.
Int J Cancer
. 2011 Jul;
130(11):2728-33.
PMID: 21792887
The nuclear factor kappa B (NFκB) pathway is essential for many human cancers. Therapeutics such as bortezomib (Velcade™) that interfere with NFκB signaling are of great clinical interest. NFκB signaling,...
16.
Roy D, Sin S, Damania B, Dittmer D
Blood
. 2011 Jun;
118(7):e32-9.
PMID: 21685375
Primary effusion lymphoma (PEL) is a diffuse-large B-cell lymphoma with poor prognosis. One hundred percent of PELs carry the genome of Kaposi sarcoma-associated herpesvirus and a majority are coinfected with...
17.
Sin S, Fakhari F, Dittmer D
J Virol
. 2010 Aug;
84(20):10653-60.
PMID: 20686032
Gammaherpesviruses, including Kaposi sarcoma-associated herpesvirus (KSHV), establish latency in B cells. We hypothesized that the KSHV latency-associated nuclear antigen (LANA/orf73) provides a selective advantage to infected B cells by driving...
18.
Bhatt A, Bhende P, Sin S, Roy D, Dittmer D, Damania B
Blood
. 2010 Mar;
115(22):4455-63.
PMID: 20299510
Primary effusion lymphoma (PEL) constitutes a subset of non-Hodgkin lymphoma whose incidence is highly increased in the context of HIV infection. Kaposi sarcoma-associated herpesvirus is the causative agent of PEL....
19.
Petre C, Sin S, Dittmer D
J Virol
. 2006 Nov;
81(4):1912-22.
PMID: 17121789
The Kaposi's sarcoma-associated herpesvirus (KSHV/HHV8) is associated with Kaposi's sarcoma (KS) as well as primary effusion lymphomas (PEL). The expression of viral proteins capable of inactivating the p53 tumor suppressor...
20.
Sin S, Roy D, Wang L, Staudt M, Fakhari F, Patel D, et al.
Blood
. 2006 Nov;
109(5):2165-73.
PMID: 17082322
The antitumor potency of the mTOR inhibitor rapamycin (sirolimus) is the subject of intense investigations. Primary effusion lymphoma (PEL) appears as an AIDS-defining lymphoma and like Kaposi sarcoma has been...