Sandy D Westerheide
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Explore the profile of Sandy D Westerheide including associated specialties, affiliations and a list of published articles.
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28
Citations
1531
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Recent Articles
1.
Lugano D, Barrett L, Chaput D, Park M, Westerheide S
RNA Biol
. 2023 Dec;
21(1):1-11.
PMID: 38126797
The Cell Division Cycle and Apoptosis Regulator (CCAR) protein family members have recently emerged as regulators of alternative splicing and transcription, as well as having other key physiological functions. For...
2.
de Thonel A, Ahlskog J, Daupin K, Dubreuil V, Berthelet J, Chaput C, et al.
Nat Commun
. 2023 Sep;
14(1):6067.
PMID: 37770591
No abstract available.
3.
de Thonel A, Ahlskog J, Daupin K, Dubreuil V, Berthelet J, Chaput C, et al.
Nat Commun
. 2022 Nov;
13(1):7002.
PMID: 36385105
Patients carrying autosomal dominant mutations in the histone/lysine acetyl transferases CBP or EP300 develop a neurodevelopmental disorder: Rubinstein-Taybi syndrome (RSTS). The biological pathways underlying these neurodevelopmental defects remain elusive. Here,...
4.
Barrett L, Westerheide S
Front Aging
. 2022 Jul;
3:861761.
PMID: 35821825
The decline of proteostasis is a hallmark of aging that is, in part, affected by the dysregulation of the heat shock response (HSR), a highly conserved cellular response to proteotoxic...
5.
Deonarine A, Walker M, Westerheide S
Cell Stress Chaperones
. 2021 Jan;
26(2):417-431.
PMID: 33392968
The transcription factor heat shock factor-1 (HSF-1) regulates the heat shock response (HSR), a cytoprotective response induced by proteotoxic stresses. Data from model organisms has shown that HSF-1 also has...
6.
Brunquell J, Raynes R, Bowers P, Morris S, Snyder A, Lugano D, et al.
Aging Cell
. 2018 Jul;
17(5):e12813.
PMID: 30003683
Defects in protein quality control during aging are central to many human diseases, and strategies are needed to better understand mechanisms of controlling the quality of the proteome. The heat-shock...
7.
Brunquell J, Snyder A, Cheng F, Westerheide S
PLoS One
. 2017 Aug;
12(8):e0183445.
PMID: 28837599
The ability of an organism to sense and adapt to environmental stressors is essential for proteome maintenance and survival. The highly conserved heat shock response is a survival mechanism employed...
8.
Paullin T, Powell C, Menzie C, Hill R, Cheng F, Martyniuk C, et al.
PLoS One
. 2017 Aug;
12(8):e0182930.
PMID: 28793334
Ovarian cancer is the most lethal gynecological cancer, with over 200,000 women diagnosed each year and over half of those cases leading to death. These poor statistics are related to...
9.
Brunquell J, Morris S, Snyder A, Westerheide S
Cell Stress Chaperones
. 2017 Jul;
23(1):65-75.
PMID: 28674941
As the population ages, there is a critical need to uncover strategies to combat diseases of aging. Studies in the soil-dwelling nematode Caenorhabditis elegans have demonstrated the protective effects of...
10.
Woo J, Liu T, Trotter C, Fang C, De Narvaez E, LePochat P, et al.
Nat Commun
. 2017 Jun;
8:15558.
PMID: 28585542
Although multiple CHCHD10 mutations are associated with the spectrum of familial and sporadic frontotemporal dementia-amyotrophic lateral sclerosis (FTD-ALS) diseases, neither the normal function of endogenous CHCHD10 nor its role in...