Sandro Cosconati
Overview
Explore the profile of Sandro Cosconati including associated specialties, affiliations and a list of published articles.
Author names and details appear as published. Due to indexing inconsistencies, multiple individuals may share a name, and a single author may have variations. MedLuna displays this data as publicly available, without modification or verification
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Articles
134
Citations
1665
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0
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Recent Articles
1.
Savadi P, Casale A, Roggia M, Conte G, Lozano M, Lopez V, et al.
Int J Pharm
. 2025 Feb;
673:125398.
PMID: 39999901
Mucosal drug delivery offers a promising non-invasive approach in pharmaceutical sciences but faces challenges from the protective mucus layer on mucosal surfaces, limiting drug absorption. Polymeric nanoparticles (NPs) have emerged...
2.
Previti S, Calcaterra E, Di Chio C, Natale B, Waqas M, Bogacz M, et al.
Eur J Med Chem
. 2025 Feb;
288:117389.
PMID: 39970727
In this structure-activity relationship (SAR) study, we report the development of rhodesain-targeting peptidomimetics with antitrypanosomal activity. The new compounds (SPR65-SPR80) feature the 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid (Tic) moiety as conformationally constrained Phe...
3.
Mottola S, Bene A, Mazzarella V, Cutolo R, Boccino I, Merlino F, et al.
Ultrason Sonochem
. 2025 Feb;
114:107257.
PMID: 39923348
The integration of low-frequency ultrasound with Solid-Phase Peptide Synthesis (SPPS) was explored to establish a Sustainable Ultrasound-assisted Solid-Phase Peptide Synthesis (SUS-SPPS) method. This innovative approach significantly reduces solvent consumption, washing...
4.
Salerno S, Barresi E, Roggia M, Natale B, Marzano S, Hyeraci M, et al.
ACS Med Chem Lett
. 2024 Nov;
15(11):1875-1883.
PMID: 39563818
Here, we explored the benzothiopyranoindole scaffold to develop antiproliferative agents with a polypharmacological profile targeting both G-quadruplex (G4)-structures and Topoisomerase (Topo) I enzyme. In a preliminary optimization phase, compound was...
5.
Poggetti V, Angeloni E, Germelli L, Natale B, Waqas M, Sarno G, et al.
ACS Chem Neurosci
. 2024 Nov;
16(1):1-15.
PMID: 39545683
In searching for putative new therapeutic strategies to treat neurodegenerative diseases, the mitochondrial 18 kDa translocator protein (TSPO) and cerebral isoforms of carbonic anhydrase (CA) were exploited as potential targets....
6.
Tomassi S, Natale B, Roggia M, Amato L, De Rosa C, Della Corte C, et al.
RSC Med Chem
. 2024 Nov;
PMID: 39512947
Non-small cell lung cancer (NSCLC), the leading cause of cancer-related mortality worldwide, poses a formidable challenge due to its heterogeneity and the emergence of resistance to targeted therapies. While initially...
7.
Trotta A, Mazzarella V, Roggia M, DAniello A, Bene A, Vetrei C, et al.
Eur J Med Chem
. 2024 Sep;
279:116911.
PMID: 39348763
Macrocyclization presents a valuable strategy for enhancing the pharmacokinetic and pharmacodynamic profiles of short bioactive peptides. The exploration of various macrocyclic characteristics, such as crosslinking tethers, ring size, and orientation,...
8.
Patacchini E, Madia V, Albano A, Ruggieri G, Messore A, Ialongo D, et al.
ACS Med Chem Lett
. 2024 Sep;
15(9):1533-1540.
PMID: 39291012
The HIV-1 integrase (IN) plays a critical role in the viral lifecycle by integrating the viral DNA into the host chromosome. The catalytic function of IN has been exploited as...
9.
Roggia M, Natale B, Amendola G, Grasso N, Di Maro S, Taliani S, et al.
J Chem Inf Model
. 2024 Sep;
64(21):8299-8309.
PMID: 39276072
Cancer's persistent growth often relies on its ability to maintain telomere length and tolerate the accumulation of DNA damage. This study explores a computational approach to identify compounds that can...
10.
Trotta A, Tomassi S, Di Maiolo G, Ierano C, Vetrei C, DAlterio C, et al.
Eur J Med Chem
. 2024 Jul;
276:116669.
PMID: 39053189
The present study describes a small library of peptides derived from a potent and selective CXCR4 antagonist (3), wherein the native disulfide bond is replaced using a side-chain to tail...