Sandra M Siepka
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Explore the profile of Sandra M Siepka including associated specialties, affiliations and a list of published articles.
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Articles
15
Citations
1934
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Recent Articles
1.
Tissue-specific FAH deficiency alters sleep-wake patterns and results in chronic tyrosinemia in mice
Yang S, Siepka S, Cox K, Kumar V, de Groot M, Chelliah Y, et al.
Proc Natl Acad Sci U S A
. 2019 Oct;
116(44):22229-22236.
PMID: 31611405
Fumarylacetoacetate hydrolase (FAH) is the last enzyme in tyrosine catabolism, and mutations in the gene are associated with hereditary tyrosinemia type I (HT1 or TYRSN1) in humans. In a behavioral...
2.
Lee W, Higuchi H, Ikeda S, Macke E, Takimoto T, Pattnaik B, et al.
Elife
. 2016 Nov;
5.
PMID: 27863209
While the aging process is central to the pathogenesis of age-dependent diseases, it is poorly understood at the molecular level. We identified a mouse mutant with accelerated aging in the...
3.
Yoo S, Mohawk J, Siepka S, Shan Y, Huh S, Hong H, et al.
Cell
. 2013 Mar;
152(5):1091-105.
PMID: 23452855
Period determination in the mammalian circadian clock involves the turnover rate of the repressors CRY and PER. We show that CRY ubiquitination engages two competing E3 ligase complexes that either...
4.
Fenner D, Odili S, Hong H, Kobayashi Y, Kohsaka A, Siepka S, et al.
J Biol Chem
. 2011 Sep;
286(45):39560-72.
PMID: 21921030
We performed genome-wide mutagenesis in C57BL/6J mice using N-ethyl-N-nitrosourea to identify mutations causing high blood glucose early in life and to produce new animal models of diabetes. Of a total...
5.
Clayton D, George J, Mello C, Siepka S
Dev Neurobiol
. 2008 Nov;
69(2-3):124-40.
PMID: 19023859
Songbirds are appreciated for the insights they provide into regulated neural plasticity. Here, we describe the comparative analysis and brain expression of two gene sequences encoding probable regulators of synaptic...
6.
Siepka S, Yoo S, Park J, Lee C, Takahashi J
Cold Spring Harb Symp Quant Biol
. 2008 Apr;
72:251-259.
PMID: 18419282
In animals, circadian behavior can be analyzed as an integrated system, beginning with genes and leading ultimately to behavioral outputs. In the last decade, the molecular mechanism of circadian clocks...
7.
Pinto L, Eaton E, Chen B, Fleisher J, Shuster D, McCauley J, et al.
Mamm Genome
. 2008 Jan;
19(1):2-14.
PMID: 18167028
We mutagenized male BTBR mice with N-ethyl-N-nitrosourea and screened 1315 of their G3 offspring for airway hyperresponsiveness. A phenovariant G3 mouse with exaggerated methacholine bronchoconstrictor response was identified and his...
8.
Siepka S, Yoo S, Park J, Song W, Kumar V, Hu Y, et al.
Cell
. 2007 Apr;
129(5):1011-23.
PMID: 17462724
Using a forward genetics ENU mutagenesis screen for recessive mutations that affect circadian rhythmicity in the mouse, we isolated a long period (approximately 26 hr) circadian mutant named Overtime (Ovtm)....
9.
Generation, identification and functional characterization of the nob4 mutation of Grm6 in the mouse
Pinto L, Vitaterna M, Shimomura K, Siepka S, Balannik V, McDearmon E, et al.
Vis Neurosci
. 2007 Apr;
24(1):111-23.
PMID: 17430614
We performed genome-wide chemical mutagenesis of C57BL/6J mice using N-ethyl-N-nitrosourea (ENU). Electroretinographic screening of the third generation offspring revealed two G3 individuals from one G1 family with a normal a-wave...
10.
Moran J, Bolton A, Tran P, Brown A, Dwyer N, Manning D, et al.
Genome Res
. 2006 Feb;
16(3):436-40.
PMID: 16461637
Phenotype-driven genetics can be used to create mouse models of human disease and birth defects. However, the utility of these mutant models is limited without identification of the causal gene....