Sandra Kelly
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Explore the profile of Sandra Kelly including associated specialties, affiliations and a list of published articles.
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10
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179
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Recent Articles
1.
Kuppan P, Wong J, Kelly S, Lin J, Worton J, Castro C, et al.
Pharmaceutics
. 2023 Sep;
15(9).
PMID: 37765170
One strategy to prevent islet rejection is to create a favorable immune-protective local environment at the transplant site. Herein, we utilize localized cyclosporine A (CsA) delivery to islet grafts via...
2.
Polishevska K, Kelly S, Kuppan P, Seeberger K, Aggarwal S, Paramor J, et al.
Pharmaceutics
. 2023 Apr;
15(4).
PMID: 37111623
Beta cell replacement therapies can restore glycemic control to select individuals living with type 1 diabetes. However, the obligation of lifelong immunosuppression restricts cell therapies from replacing exogenous insulin administration....
3.
Seeberger K, Salama B, Kelly S, Rosko M, Castro C, DesAulniers J, et al.
Xenotransplantation
. 2023 Feb;
30(2):e12793.
PMID: 36748727
Neonatal porcine islets (NPIs) are a source of islets for xenotransplantation. In the pig, the pancreatic lobes remain separate, thus, when optimizing NPI isolation, the pancreatic lobes included in the...
4.
Kuppan P, Kelly S, Seeberger K, Castro C, Rosko M, Pepper A, et al.
Polymers (Basel)
. 2022 Mar;
14(6).
PMID: 35335450
The subcutaneous space is currently being pursued as an alternative transplant site for ß-cell replacement therapies due to its retrievability, minimally invasive procedure and potential for graft imaging. However, implantation...
5.
Kuppan P, Seeberger K, Kelly S, Rosko M, Adesida A, Pepper A, et al.
Xenotransplantation
. 2020 Jan;
27(4):e12581.
PMID: 31930606
Background: Cell transplantation has been widely recognized as a curative treatment strategy for variety of diseases including type I diabetes (T1D). Broader patient inclusion for this therapeutic option is restricted...
6.
Kuppan P, Kelly S, Polishevska K, Hojanepesov O, Seeberger K, Korbutt G, et al.
Am J Transplant
. 2019 Oct;
20(3):714-725.
PMID: 31650674
The broad application of ß cell transplantation for type 1 diabetes is hindered by the requisite of lifelong systemic immunosuppression. This study examines the utility of localized islet graft drug...
7.
Hsia M, OMalley R, Cartwright A, Nieu R, Gordon S, Kelly S, et al.
Plant J
. 2017 Apr;
91(3):361-370.
PMID: 28432803
Due to a large and growing collection of genomic and experimental resources, Brachypodium distachyon has emerged as a powerful experimental model for the grasses. To add to these resources we...
8.
Uwiera R, Mangat R, Kelly S, Uwiera T, Proctor S
J Vis Exp
. 2016 Mar;
(109).
PMID: 27023826
Catheterization of the intestinal lymph trunk in neonatal pigs is a technique allowing for the long-term collection of large quantities of intestinal (central) efferent lymph. Importantly, the collection of central...
9.
Wang X, Chow F, Oka T, Hao L, Lopez-Campistrous A, Kelly S, et al.
Circulation
. 2009 Apr;
119(18):2480-9.
PMID: 19398663
Background: Excessive stimulation of Gq protein-coupled receptors by cognate vasoconstrictor agonists induces a variety of cardiovascular processes, including hypertension and hypertrophy. Here, we report that matrix metalloproteinase-7 (MMP-7) and a...
10.
Gao S, Kinzig K, Aja S, Scott K, Keung W, Kelly S, et al.
Proc Natl Acad Sci U S A
. 2007 Oct;
104(44):17358-63.
PMID: 17956983
Hypothalamic fatty acid metabolism has recently been implicated in the controls of food intake and energy homeostasis. We report that intracerebroventricular (ICV) injection of leptin, concomitant with inhibiting AMP-activated kinase...