Sandra Espada
Overview
Explore the profile of Sandra Espada including associated specialties, affiliations and a list of published articles.
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Articles
11
Citations
280
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0
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Recent Articles
1.
Brinch S, Amundsen-Isaksen E, Espada S, Hammarstrom C, Aizenshtadt A, Olsen P, et al.
Cancer Res Commun
. 2023 Mar;
2(4):233-245.
PMID: 36873622
Significance: This study uncovers the effectiveness and therapeutic window for a novel tankyrase inhibitor in mouse tumor models.
2.
Mygland L, Brinch S, Strand M, Olsen P, Aizenshtadt A, Lund K, et al.
iScience
. 2021 Aug;
24(7):102807.
PMID: 34337362
Small-molecule tankyrase 1 and tankyrase 2 (TNKS1/2) inhibitors are effective antitumor agents in selected tumor cell lines and mouse models. Here, we characterized the response signatures and the in-depth mechanisms...
3.
Espada S, Stavik B, Holm S, Sagen E, Bjerkeli V, Skjelland M, et al.
Biochem Biophys Res Commun
. 2017 Jul;
491(2):442-448.
PMID: 28712870
Endoplasmic reticulum (ER) stress has been shown to play a key role during the initiation and clinical progression of the cardiovascular diseases, such as atherosclerosis. We have recently shown that...
4.
Stavik B, Holm S, Espada S, Iversen N, Sporsheim B, Bjerkeli V, et al.
Thromb Res
. 2017 May;
155:31-37.
PMID: 28482260
Introduction: Tissue factor (TF) pathway inhibitor (TFPI) is the physiological inhibitor of TF induced blood coagulation and two isoforms exists, TFPIα and TFPIβ. In atherosclerotic plaques, TFPI may inhibit TF...
5.
Stavik B, Espada S, Cui X, Iversen N, Holm S, Mowinkel M, et al.
Biochim Biophys Acta
. 2016 Jan;
1862(4):670-678.
PMID: 26826018
Neovascularization and hemorrhaging are evident in advanced atherosclerotic plaques due to hypoxic conditions, and mediate the accumulation of metabolic substrates, inflammatory cells, lipids, and other blood born factors inside the...
6.
McCreath K, Espada S, Galvez B, Benito M, de Molina A, Sepulveda P, et al.
Diabetes
. 2014 Oct;
64(4):1154-67.
PMID: 25352636
A number of metabolites have signaling properties by acting through G-protein-coupled receptors. Succinate, a Krebs cycle intermediate, increases after dysregulated energy metabolism and can bind to its cognate receptor succinate...
7.
Delgado-Buenrostro N, Medina-Reyes E, Lastres-Becker I, Freyre-Fonseca V, Ji Z, Hernandez-Pando R, et al.
Environ Toxicol
. 2014 Mar;
30(7):782-92.
PMID: 24615891
Titanium dioxide nanoparticles (TiO2 NPs) have been classified as possibly carcinogenic to humans and they are an important nanomaterial widely used in pharmaceutical and paint industries. Inhalation is one of...
8.
Rojo A, Medina-Campos O, Rada P, Zuniga-Toala A, Lopez-Gazcon A, Espada S, et al.
Free Radic Biol Med
. 2011 Dec;
52(2):473-87.
PMID: 22142471
Defense against oxidative stress is executed by an antioxidant program that is tightly controlled by the transcription factor Nrf2. The stability of Nrf2 involves the interaction of two degradation domains,...
9.
Espada S, Ortega F, Molina-Jijon E, Rojo A, Perez-Sen R, Pedraza-Chaverri J, et al.
Free Radic Biol Med
. 2010 May;
49(3):416-26.
PMID: 20447456
Although extracellular purines may have both trophic and apoptotic functions in the brain depending on the targeted purine receptor and cell type, little is known about the role of specific...
10.
Espada S, Rojo A, Salinas M, Cuadrado A
J Neurochem
. 2009 Jun;
110(3):1107-19.
PMID: 19558456
In this study, we provide evidence that the muscarinic M1 receptor targets NF-E2-related factor-2 (Nrf2), a transcription factor that regulates the expression of genes containing antioxidant response elements (AREs) in...