Aleksandra Aizenshtadt
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Explore the profile of Aleksandra Aizenshtadt including associated specialties, affiliations and a list of published articles.
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21
Citations
101
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Recent Articles
1.
Kogler S, Skottvoll F, Hruskova H, Rise F, Aizenshtadt A, Krauss S, et al.
Anal Chem
. 2025 Feb;
97(9):4923-4931.
PMID: 39995235
The use of organoids and organ-on-chip technologies as nonanimal methodologies in drug discovery and personalized medicine is rapidly expanding. However, the complexity and small volumes of organoid culture samples present...
2.
Wilhelmsen I, Combriat T, Dalmao-Fernandez A, Stokowiec J, Wang C, Olsen P, et al.
Stem Cell Res Ther
. 2024 Jul;
15(1):223.
PMID: 39044210
Background: Hepatic stellate cells (HSC) have numerous critical roles in liver function and homeostasis, while they are also known for their importance during liver injury and fibrosis. There is therefore...
3.
Kogler S, Pedersen G, Martinez-Ramirez F, Aizenshtadt A, Busek M, Krauss S, et al.
Anal Chem
. 2024 Jul;
96(29):12129-12138.
PMID: 38985547
As organoids and organ-on-chip (OoC) systems move toward preclinical and clinical applications, there is an increased need for method validation. Using a liquid chromatography-mass spectrometry (LC-MS)-based approach, we developed a...
4.
Wang C, Abadpour S, Aizenshtadt A, Dalmao-Fernandez A, Hoyem M, Wilhelmsen I, et al.
Front Bioeng Biotechnol
. 2024 Jun;
12:1392575.
PMID: 38933536
Stem cell-derived islets (SC-islets) are not only an unlimited source for cell-based therapy of type 1 diabetes but have also emerged as an attractive material for modeling diabetes and conducting...
5.
Wang C, Abadpour S, Olsen P, Wang D, Stokowiec J, Chera S, et al.
Transpl Int
. 2024 Feb;
37:11900.
PMID: 38304198
The generation of insulin-producing cells from human-induced pluripotent stem cells holds great potential for diabetes modeling and treatment. However, existing protocols typically involve incubating cells with un-physiologically high concentrations of...
6.
Hruskova H, Olsen C, reminek R, Wang C, Aizenshtadt A, Krauss S, et al.
J Chromatogr A
. 2024 Jan;
1717:464669.
PMID: 38278130
Organoids are 3D cell cultures with microanatomies mimicking aspects of real organs, useful for e.g. animal-free studies of development, disease, and drug discovery. The cell medium of organoid models of...
7.
Cunha A, Schuelke C, Mesri A, Ruud S, Aizenshtadt A, Ferrari G, et al.
Sensors (Basel)
. 2024 Jan;
24(2).
PMID: 38257668
Implantable cell replacement therapies promise to completely restore the function of neural structures, possibly changing how we currently perceive the onset of neurodegenerative diseases. One of the major clinical hurdles...
8.
Aizenshtadt A, Wang C, Abadpour S, Menezes P, Wilhelmsen I, Dalmao-Fernandez A, et al.
Adv Healthc Mater
. 2024 Jan;
13(13):e2303785.
PMID: 38221504
Type 2 diabetes mellitus (T2DM), obesity, and metabolic dysfunction-associated steatotic liver disease (MASLD) are epidemiologically correlated disorders with a worldwide growing prevalence. While the mechanisms leading to the onset and...
9.
Olsen C, Wang C, Aizenshtadt A, Abadpour S, Lundanes E, Sved Skottvoll F, et al.
Electrophoresis
. 2023 Aug;
44(21-22):1682-1697.
PMID: 37574258
For studying stem cell-derived islet organoids (SC-islets) in an organ-on-chip (OoC) platform, we have developed a reversed-phase liquid chromatography-tandem mass spectrometry (RPLC-MS/MS) method allowing for simultaneous determination of insulin, somatostatin-14,...
10.
Wilhelmsen I, Amirola Martinez M, Stokowiec J, Wang C, Aizenshtadt A, Krauss S
Front Bioeng Biotechnol
. 2023 Aug;
11:1223737.
PMID: 37560536
There is a significant need for predictive and stable human liver representations for disease modeling and drug testing. Hepatic stellate cells (HSCs) and liver sinusoidal endothelial cells (LSECs) are important...