Sandra C P de Castro
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Explore the profile of Sandra C P de Castro including associated specialties, affiliations and a list of published articles.
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26
Citations
573
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Recent Articles
11.
de Castro S, Gustavsson P, Marshall A, Gordon W, Galea G, Nikolopoulou E, et al.
Hum Mol Genet
. 2018 Sep;
27(24):4218-4230.
PMID: 30189017
The genetic basis of human neural tube defects (NTDs), such as anencephaly and spina bifida (SB), is complex and heterogeneous. Grainyhead-like genes represent candidates for involvement in NTDs based on...
12.
de Castro S, Hirst C, Savery D, Rolo A, Lickert H, Andersen B, et al.
Dev Biol
. 2018 Feb;
435(2):130-137.
PMID: 29397878
Failure of neural tube closure leads to neural tube defects (NTDs), common congenital abnormalities in humans. Among the genes whose loss of function causes NTDs in mice, Grainyhead-like3 (Grhl3) is...
13.
Sudiwala S, de Castro S, Leung K, Brosnan J, Brosnan M, Mills K, et al.
Biochimie
. 2016 Mar;
126:63-70.
PMID: 26924399
The curly tail mouse provides a model for neural tube defects (spina bifida and exencephaly) that are resistant to prevention by folic acid. The major ct gene, responsible for spina...
14.
Norris F, Siow B, Cleary J, Wells J, de Castro S, Ordidge R, et al.
Magn Reson Med
. 2014 Mar;
73(2):731-9.
PMID: 24634098
Purpose: Advanced methodologies for visualizing novel tissue contrast are essential for phenotyping the ever-increasing number of mutant mouse embryos being generated. Although diffusion microscopic MRI (μMRI) has been used to...
15.
Leung K, de Castro S, Savery D, Copp A, Greene N
Brain
. 2013 Aug;
136(Pt 9):2836-41.
PMID: 23935126
Closure of the neural tube during embryogenesis is a crucial step in development of the central nervous system. Failure of this process results in neural tube defects, including spina bifida...
16.
Robinson A, Partridge D, Malhas A, de Castro S, Gustavsson P, Thompson D, et al.
Birth Defects Res A Clin Mol Teratol
. 2013 Jun;
97(6):398-402.
PMID: 23733478
Background: Lamins are intermediate filament proteins that form a major component of the nuclear lamina, a protein complex at the surface of the inner nuclear membrane. Numerous clinically diverse conditions,...
17.
Leung K, de Castro S, Cabreiro F, Gustavsson P, Copp A, Greene N
Mol Cell Biochem
. 2013 Mar;
378(1-2):229-36.
PMID: 23483428
Folates act as co-factors for transfer of one-carbon units for nucleotide production, methylation and other biosynthetic reactions. Comprehensive profiling of multiple folates can be achieved using liquid chromatography tandem mass...
18.
de Castro S, Malhas A, Leung K, Gustavsson P, Vaux D, Copp A, et al.
PLoS Genet
. 2012 Nov;
8(11):e1003059.
PMID: 23166514
Neural tube defects (NTDs), including spina bifida and anencephaly, are common birth defects whose complex multigenic causation has hampered efforts to delineate their molecular basis. The effect of putative modifier...
19.
Brouns M, de Castro S, Terwindt-Rouwenhorst E, Massa V, Hekking J, Hirst C, et al.
Hum Mol Genet
. 2011 Jan;
20(8):1536-46.
PMID: 21262862
Cranial neural tube defects (NTDs) occur in mice carrying mutant alleles of many different genes, whereas isolated spinal NTDs (spina bifida) occur in fewer models, despite being common human birth...
20.
de Castro S, Leung K, Savery D, Burren K, Rozen R, Copp A, et al.
Birth Defects Res A Clin Mol Teratol
. 2010 Jul;
88(8):612-8.
PMID: 20589880
Background: Folate one-carbon metabolism has been implicated as a determinant of susceptibility to neural tube defects (NTDs), owing to the preventive effect of maternal folic acid supplementation and the higher...