Samuel Walpole
Overview
Explore the profile of Samuel Walpole including associated specialties, affiliations and a list of published articles.
Author names and details appear as published. Due to indexing inconsistencies, multiple individuals may share a name, and a single author may have variations. MedLuna displays this data as publicly available, without modification or verification
Snapshot
Snapshot
Articles
14
Citations
194
Followers
0
Related Specialties
Related Specialties
Top 10 Co-Authors
Top 10 Co-Authors
Published In
Published In
Affiliations
Affiliations
Soon will be listed here.
Recent Articles
1.
Nepravishta R, Ramirez-Cardenas J, Rocha G, Walpole S, Hicks T, Monaco S, et al.
J Med Chem
. 2024 Jun;
67(12):10025-10034.
PMID: 38848103
Low-affinity protein-ligand interactions are important for many biological processes, including cell communication, signal transduction, and immune responses. Structural characterization of these complexes is also critical for the development of new...
2.
Rocha G, Ramirez-Cardenas J, Carmen Padilla-Perez M, Walpole S, Nepravishta R, Isabel Garcia-Moreno M, et al.
Anal Chem
. 2024 Jan;
96(2):615-619.
PMID: 38165272
STD NMR spectroscopy is a powerful ligand-observed NMR tool for screening and characterizing the interactions of small molecules and low molecular weight fragments with a given macromolecule, identifying the main...
3.
Huettner I, Krumm S, Serna S, Brzezicka K, Monaco S, Walpole S, et al.
Cell Rep
. 2022 Mar;
38(13):110611.
PMID: 35354052
The HIV-1 Envelope glycoprotein (Env) is the sole target for broadly neutralizing antibodies (bnAbs). Env is heavily glycosylated with host-derived N-glycans, and many bnAbs bind to, or are dependent upon,...
4.
Wu H, Crost E, Owen C, van Bakel W, Martinez Gascuena A, Latousakis D, et al.
PLoS Biol
. 2021 Dec;
19(12):e3001498.
PMID: 34936658
The human gut symbiont Ruminococcus gnavus displays strain-specific repertoires of glycoside hydrolases (GHs) contributing to its spatial location in the gut. Sequence similarity network analysis identified strain-specific differences in blood-group...
5.
Monaco S, Walpole S, Doukani H, Nepravishta R, Martinez-Bailen M, Carmona A, et al.
Chemistry
. 2020 May;
26(44):10024-10034.
PMID: 32449563
Ligand-based NMR techniques to study protein-ligand interactions are potent tools in drug design. Saturation transfer difference (STD) NMR spectroscopy stands out as one of the most versatile techniques, allowing screening...
6.
Wu H, Rebello O, Crost E, Owen C, Walpole S, Bennati-Granier C, et al.
Cell Mol Life Sci
. 2020 Apr;
78(2):675-693.
PMID: 32333083
The availability and repartition of fucosylated glycans within the gastrointestinal tract contributes to the adaptation of gut bacteria species to ecological niches. To access this source of nutrients, gut bacteria...
7.
Bidula S, Cromer B, Walpole S, Angulo J, Stokes L
Sci Rep
. 2019 Mar;
9(1):3231.
PMID: 30824738
P2X7 receptors are important in the regulation of inflammatory responses and immune responses to intracellular pathogens such as Mycobacterium tuberculosis and Toxoplasma gondii. Enhancement of P2X7 receptor responses may be...
8.
Walpole S, Monaco S, Nepravishta R, Angulo J
Methods Enzymol
. 2019 Jan;
615:423-451.
PMID: 30638536
STD NMR is a powerful ligand-based tool for screening small molecules and low molecular weight fragments for their interaction with a given macromolecule. Such information is invaluable both in the...
9.
Dhuna K, Felgate M, Bidula S, Walpole S, Bibic L, Cromer B, et al.
Mol Pharmacol
. 2018 Dec;
95(2):210-221.
PMID: 30545933
We investigated the selectivity of protopanaxadiol ginsenosides from acting as positive allosteric modulators on P2X receptors. ATP-induced responses were measured in stable cell lines overexpressing human P2X4 using a YOPRO-1...
10.
Nepravishta R, Walpole S, Tailford L, Juge N, Angulo J
Chembiochem
. 2018 Nov;
20(3):340-344.
PMID: 30379391
Differential epitope mapping saturation transfer difference (DEEP-STD) NMR spectroscopy is a recently developed powerful approach for elucidating the structure and pharmacophore of weak protein-ligand interactions, as it reports key information...