Leanne Stokes
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Explore the profile of Leanne Stokes including associated specialties, affiliations and a list of published articles.
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49
Citations
1108
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Recent Articles
1.
Bidula S, Piyasirananda W, Bielecka H, Bibic L, Beekman A, Stokes L
Purinergic Signal
. 2024 Oct;
PMID: 39436616
P2X7 is an emerging therapeutic target for several disorders and diseases due to its role in inflammatory signalling. This study aimed to exploit the unique chemical libraries of plants used...
2.
Angsusing J, Singh S, Samee W, Tadtong S, Stokes L, OConnell M, et al.
Pharmaceuticals (Basel)
. 2024 Aug;
17(8).
PMID: 39204123
Yataprasen (YTPS) remedy formulary, a national Thai traditional medicine formulary, comprises 13 herbal plants. It has been extensively prescribed to relieve osteoarthritis and musculoskeletal pain in the Thai traditional medicine...
3.
Sluyter R, McEwan T, Sophocleous R, Stokes L
J Immunol Methods
. 2024 Feb;
526:113626.
PMID: 38311008
The P2X4 receptor is a trimeric ligand-gated ion channel activated by adenosine 5'-triphosphate (ATP). P2X4 is present in immune cells with emerging roles in inflammation and immunity, and related disorders....
4.
Dhuna K, Helliwell R, De Luca S, Spencer S, Stokes L
Purinergic Signal
. 2023 Apr;
20(1):65-71.
PMID: 37055674
The activation of P2X7 is a well-known stimulus for the NLRP3-caspase 1 inflammasome and subsequent rapid IL-1β secretion from monocytes and macrophages. Here we show that positive allosteric modulators of...
5.
Sluyter R, Sophocleous R, Stokes L
Neuropharmacology
. 2022 Dec;
224:109358.
PMID: 36464207
Fifty years ago, the late Geoffrey Burnstock described the concept of purinergic nerves and transmission bringing into existence the broader concepts of purinergic signaling including P2X receptors. These receptors are...
6.
Dane C, Stokes L, Jorgensen W
Expert Opin Ther Pat
. 2022 Apr;
32(7):769-790.
PMID: 35443137
Introduction: Purinergic receptors play a critical role in neurotransmission, and modulation of complex physiological functions and thus have implications in numerous disease states. The past decade has seen substantial progress...
7.
Piyasirananda W, Beekman A, Ganesan A, Bidula S, Stokes L
Mol Pharmacol
. 2020 Dec;
99(2):163-174.
PMID: 33334897
P2X7 is an important ligand-gated ion channel expressed in multiple immune cell populations. This study aimed to investigate the chemical requirements of triterpenoid glycosides within a new binding pocket to...
8.
Bibic L, Stokes L
Front Mol Neurosci
. 2020 Oct;
13:166.
PMID: 33071753
The P2X7 receptor (P2X7) is a cell surface ligand-gated ion channel, activated by its physiological nucleotide agonist ATP and a synthetic analog (BzATP). However, it has also been suggested that...
9.
Stokes L, Bidula S, Bibic L, Allum E
Front Pharmacol
. 2020 Jun;
11:627.
PMID: 32477120
The family of ligand-gated ion channels known as P2X receptors were discovered several decades ago. Since the cloning of the seven P2X receptors (P2X1-P2X7), a huge research effort has elucidated...
10.
Zusso M, Stokes L, Moro S, Giusti P
Front Pharmacol
. 2020 Apr;
11:480.
PMID: 32322215
No abstract available.