Samuel J Seguin
Overview
Explore the profile of Samuel J Seguin including associated specialties, affiliations and a list of published articles.
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Articles
6
Citations
633
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0
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Recent Articles
1.
Ganassi M, Mateju D, Bigi I, Mediani L, Poser I, Lee H, et al.
Mol Cell
. 2016 Aug;
63(5):796-810.
PMID: 27570075
Stress granules (SGs) are ribonucleoprotein complexes induced by stress. They sequester mRNAs and disassemble when the stress subsides, allowing translation restoration. In amyotrophic lateral sclerosis (ALS), aberrant SGs cannot disassemble...
2.
Crippa V, Cicardi M, Ramesh N, Seguin S, Ganassi M, Bigi I, et al.
Hum Mol Genet
. 2016 Jul;
25(18):3908-3924.
PMID: 27466192
Aggregation of TAR-DNA-binding protein 43 (TDP-43) and of its fragments TDP-25 and TDP-35 occurs in amyotrophic lateral sclerosis (ALS). TDP-25 and TDP-35 act as seeds for TDP-43 aggregation, altering its...
3.
Fuchs M, Poirier D, Seguin S, Lambert H, Carra S, Charette S, et al.
Biochem J
. 2009 Oct;
425(1):245-55.
PMID: 19845507
The molecular chaperone HspB8 [Hsp (heat-shock protein) B8] is member of the B-group of Hsps. These proteins bind to unfolded or misfolded proteins and protect them from aggregation. HspB8 has...
4.
Hytonen M, Grall A, Hedan B, Dreano S, Seguin S, Delattre D, et al.
J Hered
. 2008 Oct;
100(2):236-40.
PMID: 18854372
Dogs differ greatly in their morphological characteristics including various tail phenotypes. Congenitally short-tailed dogs are present in many breeds; however, the causative mutation located in the T-box transcription factor T...
5.
Carra S, Seguin S, Landry J
Autophagy
. 2007 Dec;
4(2):237-9.
PMID: 18094623
Protein quality control involves molecular chaperones that recognize misfolded proteins thereby preventing their aggregation, and associated co-chaperones that modulate substrate sorting between renaturation and proteasomal degradation. We recently described a...
6.
Carra S, Seguin S, Lambert H, Landry J
J Biol Chem
. 2007 Nov;
283(3):1437-1444.
PMID: 18006506
Mutations in HspB8, a member of the B group of heat shock proteins (Hsp), have been associated with human neuromuscular disorders. However, the exact function of HspB8 is not yet...