Samuel J Klempner
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Explore the profile of Samuel J Klempner including associated specialties, affiliations and a list of published articles.
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152
Citations
4096
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Recent Articles
11.
Singh H, Lowder K, Kapner K, Kelly R, Zheng H, McCleary N, et al.
Nat Commun
. 2024 Aug;
15(1):6833.
PMID: 39122726
Preclinical studies suggest that simultaneous HER2/VEGF blockade may have cooperative effects in gastroesophageal adenocarcinomas. In a single-arm investigator initiated clinical trial for patients with untreated advanced HER2+ gastroesophageal adenocarcinoma, bevacizumab...
12.
Shitara K, Shah M, Lordick F, Bang Y, Ilson D, Van Cutsem E, et al.
Future Oncol
. 2024 Jun;
20(26):1861-1877.
PMID: 38861294
What Is This Summary About?: This is a summary of two articles. The first article is about a clinical trial called SPOTLIGHT and it was published in the medical journal...
13.
Klempner S, Cowden E, Cytryn S, Fassan M, Kawakami H, Shimada H, et al.
JCO Precis Oncol
. 2024 Jun;
8:e2400230.
PMID: 38822761
Purpose: The clinical application of PD-L1 immunohistochemistry (IHC) testing is complicated by the availability of multiple IHC assays, scoring algorithms, and cutoffs. This study assessed the analytical comparability of three...
14.
Lee G, Kim D, Smart A, Horick N, Eyler C, Roberts H, et al.
Am J Clin Oncol
. 2024 May;
47(8):373-382.
PMID: 38767086
Objective: The aim of this study was to evaluate the incidence of radiotherapy (RT)-related lymphopenia, its predictors, and association with survival in unresectable intrahepatic cholangiocarcinoma (ICC) treated with hypofractionated-RT (HF-RT)....
15.
Ho C, Gilbert M, Urtecho G, Lee H, Drew D, Klempner S, et al.
Cancer Prev Res (Phila)
. 2024 Apr;
17(8):361-376.
PMID: 38669694
There is a high unmet need for early detection approaches for diffuse gastric cancer (DGC). We examined whether the stool proteome of mouse models of gastric cancer (GC) and individuals...
16.
Yaeger R, Uboha N, Pelster M, Bekaii-Saab T, Barve M, Saltzman J, et al.
Cancer Discov
. 2024 Apr;
14(6):982-993.
PMID: 38587856
Significance: Adagrasib plus cetuximab demonstrates promising clinical activity and tolerable safety in heavily pretreated patients with unresectable or metastatic KRASG12C-mutated colorectal cancer. These data support a potential new standard of...
17.
Strickland M, Lander E, Gibson M, Ilson D, Ajani J, Klempner S
J Natl Compr Canc Netw
. 2024 Mar;
22(3).
PMID: 38503041
Esophageal, gastroesophageal junction, and gastric adenocarcinomas, referred to collectively as gastroesophageal adenocarcinomas (GEAs), are a major cause of global cancer-related mortality. Our increasing molecular understanding has led to the addition...
18.
Gaber C, Sarker J, Abdelaziz A, Okpara E, Lee T, Klempner S, et al.
Cancer Med
. 2024 Mar;
13(4):e7076.
PMID: 38457244
Background: Neoadjuvant chemoradiation and chemotherapy are recommended for the treatment of nonmetastatic esophageal cancer. The benefit of neoadjuvant treatment is mostly limited to patients who exhibit pathologic complete response (pCR)....
19.
An M, Mehta A, Min B, Heo Y, Wright S, Parikh M, et al.
Cancer Discov
. 2024 Feb;
14(5):766-785.
PMID: 38319303
Significance: The benefit of 5-FU/platinum with anti-PD-1 in first-line advanced gastric cancer is limited to patient subgroups. Using a trial with sequential anti-PD-1, we show coordinated induction of multicellular TME...
20.
Khazaei Monfared Y, Heidari P, Klempner S, Mahmood U, Parikh A, Hong T, et al.
Pharmaceutics
. 2023 Dec;
15(12).
PMID: 38140100
DNA is an organic molecule that is highly vulnerable to chemical alterations and breaks caused by both internal and external factors. Cells possess complex and advanced mechanisms, including DNA repair,...