Samuel J I Blackford
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Explore the profile of Samuel J I Blackford including associated specialties, affiliations and a list of published articles.
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14
Citations
672
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Recent Articles
1.
Kent D, Ng S, Syanda A, Khoshkenar P, Ronzoni R, Li C, et al.
Hepatology
. 2024 Jul;
81(3):903-916.
PMID: 38954820
Background: Alpha-1 antitrypsin deficiency (A1ATD) is a life-threatening condition caused by the inheritance of the serpin family A member 1 "Z" genetic variant driving alpha-1 antitrypsin (AAT) protein misfolding in...
2.
Blackford S, Yu T, Norman M, Syanda A, Manolakakis M, Lachowski D, et al.
Biomaterials
. 2023 Jan;
293:121982.
PMID: 36640555
Human pluripotent stem cell-derived hepatocytes (hPSC-Heps) may be suitable for treating liver diseases, but differentiation protocols often fail to yield adult-like cells. We hypothesised that replicating healthy liver niche biochemical...
3.
Syanda A, Kringstad V, Blackford S, Kjesbu J, Ng S, Ma L, et al.
Front Bioeng Biotechnol
. 2022 Mar;
9:816542.
PMID: 35308825
Intra-peritoneal placement of alginate encapsulated human induced pluripotent stem cell-derived hepatocytes (hPSC-Heps) represents a potential new bridging therapy for acute liver failure. One of the rate-limiting steps that needs to...
4.
Jobbins A, Haberman N, Artigas N, Amourda C, Paterson H, Yu S, et al.
Nucleic Acids Res
. 2022 Mar;
50(6):3379-3393.
PMID: 35293570
Pre-mRNA processing is an essential mechanism for the generation of mature mRNA and the regulation of gene expression in eukaryotic cells. While defects in pre-mRNA processing have been implicated in...
5.
Li C, Ogawa H, Ng S, Chen X, Kishimoto E, Sakabe K, et al.
JHEP Rep
. 2022 Mar;
4(4):100446.
PMID: 35284810
Background & Aims: The truncating mutations in tight junction protein 2 (TJP2) cause progressive cholestasis, liver failure, and hepatocyte carcinogenesis. Due to the lack of effective model systems, there are...
6.
Segal J, Kent D, Wesche D, Ng S, Serra M, Oules B, et al.
Nat Commun
. 2019 Jul;
10(1):3350.
PMID: 31350390
The liver parenchyma is composed of hepatocytes and bile duct epithelial cells (BECs). Controversy exists regarding the cellular origin of human liver parenchymal tissue generation during embryonic development, homeostasis or...
7.
Blackford S, Ng S, Segal J, King A, Austin A, Kent D, et al.
Stem Cells Transl Med
. 2018 Nov;
8(2):124-137.
PMID: 30456803
Recent advancements in the production of hepatocytes from human pluripotent stem cells (hPSC-Heps) afford tremendous possibilities for treatment of patients with liver disease. Validated current good manufacturing practice (cGMP) lines...
8.
Ng S, Saeb-Parsy K, Blackford S, Segal J, Serra M, Horcas-Lopez M, et al.
Biomaterials
. 2018 Aug;
182:299-311.
PMID: 30149262
Generation of human organoids from induced pluripotent stem cells (iPSCs) offers exciting possibilities for developmental biology, disease modelling and cell therapy. Significant advances towards those goals have been hampered by...
9.
Gonzalez-Cordero A, Goh D, Kruczek K, Naeem A, Fernando M, Kleine Holthaus S, et al.
Hum Gene Ther
. 2018 Mar;
29(10):1124-1139.
PMID: 29580100
Adeno-associated viral vectors are showing great promise as gene therapy vectors for a wide range of retinal disorders. To date, evaluation of therapeutic approaches has depended almost exclusively on the...
10.
Waldron P, di Marco F, Kruczek K, Ribeiro J, Graca A, Hippert C, et al.
Stem Cell Reports
. 2018 Jan;
10(2):406-421.
PMID: 29307580
Human vision relies heavily upon cone photoreceptors, and their loss results in permanent visual impairment. Transplantation of healthy photoreceptors can restore visual function in models of inherited blindness, a process...