Rachael A Pearson
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Explore the profile of Rachael A Pearson including associated specialties, affiliations and a list of published articles.
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44
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1832
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Recent Articles
1.
Sen S, Cabral de Guimaraes T, Filho A, Fabozzi L, Pearson R, Michaelides M
Ophthalmic Genet
. 2024 Nov;
:1-14.
PMID: 39544140
Stem cell-based therapy has gained importance over the past decades due to huge advances in science and technology behind the generation and directed differentiation of pluripotent cells from embryos and...
2.
Kalargyrou A, Matsuyama A, Lanning E, Khazim M, Guilfoyle S, Smith A, et al.
STAR Protoc
. 2024 Feb;
5(1):102875.
PMID: 38386547
Here, we present a protocol for isolating and culturing mouse photoreceptors in a minimal, chemically defined medium free from serum. We describe steps for retina dissection, enzymatic dissociation, photoreceptor enrichment,...
3.
Kalargyrou A, Guilfoyle S, Smith A, Ali R, Pearson R
Front Mol Neurosci
. 2023 Jan;
15:1042469.
PMID: 36710933
The retina encompasses a network of neurons, glia and epithelial and vascular endothelia cells, all coordinating visual function. Traditionally, molecular information exchange in this tissue was thought to be orchestrated...
4.
Pearson R, Wicha S, Okour M
J Clin Pharmacol
. 2022 Sep;
63(2):151-165.
PMID: 36088583
Combination therapies have become increasingly researched and used in the treatment and management of complex diseases due to their ability to increase the chances for better efficacy and decreased toxicity....
5.
Aghaizu N, Warre-Cornish K, Robinson M, Ali R, Pearson R
STAR Protoc
. 2021 Dec;
2(4):101008.
PMID: 34917982
The developing retina undergoes dynamic organizational changes involving significant intra-retinal motility of the encompassing cells. Here, we present a protocol for tracking retinal cell motility in live explanted mouse retinae....
6.
Kalargyrou A, Basche M, Hare A, West E, Smith A, Ali R, et al.
EMBO Rep
. 2021 Sep;
22(11):e53732.
PMID: 34494703
Neuronal communication is typically mediated via synapses and gap junctions. New forms of intercellular communication, including nanotubes (NTs) and extracellular vesicles (EVs), have been described for non-neuronal cells, but their...
7.
Aghaizu N, Warre-Cornish K, Robinson M, Waldron P, Maswood R, Smith A, et al.
Cell Rep
. 2021 Aug;
36(5):109461.
PMID: 34348137
In development, almost all stratified neurons must migrate from their birthplace to the appropriate neural layer. Photoreceptors reside in the most apical layer of the retina, near their place of...
8.
Hippert C, Graca A, Basche M, Kalargyrou A, Georgiadis A, Ribeiro J, et al.
Glia
. 2021 May;
69(9):2272-2290.
PMID: 34029407
Gliosis is a complex process comprising upregulation of intermediate filament (IF) proteins, particularly glial fibrillary acidic protein (GFAP) and vimentin, changes in glial cell morphology (hypertrophy) and increased deposition of...
9.
Ribeiro J, Procyk C, West E, OHara-Wright M, Martins M, Khorasani M, et al.
Cell Rep
. 2021 Apr;
35(3):109022.
PMID: 33882303
Age-related macular degeneration and other macular diseases result in the loss of light-sensing cone photoreceptors, causing irreversible sight impairment. Photoreceptor replacement may restore vision by transplanting healthy cells, which must...
10.
Nguyen T, Pearson R, Mohamed M, Schladt D, Berglund D, Rivers Z, et al.
J Clin Pharm Ther
. 2020 Jul;
45(6):1457-1465.
PMID: 32662547
What Is Known And Objective: Pharmacogenomic biomarkers are now used in many clinical care settings and represent one of the successes of precision medicine. Genetic variants are associated with pharmacokinetic...