Samuel D Perli
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Explore the profile of Samuel D Perli including associated specialties, affiliations and a list of published articles.
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7
Citations
599
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Recent Articles
1.
Gohil N, Bhattacharjee G, Lam N, Perli S, Singh V
Prog Mol Biol Transl Sci
. 2021 May;
180:141-151.
PMID: 33934835
The advancement gained over the past couple of decades in clustered regularly interspaced short palindromic repeats and CRISPR associated proteins (CRISPR-Cas) systems have revolutionized the field of synthetic biology, therapeutics,...
2.
Takahashi K, Jeong D, Wang S, Narita M, Jin X, Iwasaki M, et al.
Cell Rep
. 2020 Jun;
31(9):107715.
PMID: 32492424
Previous studies have suggested that the loss of the translation initiation factor eIF4G1 homolog NAT1 induces excessive self-renewability of naive pluripotent stem cells (PSCs); yet the role of NAT1 in...
3.
Perli S, Cui C, Lu T
Science
. 2016 Aug;
353(6304).
PMID: 27540006
The ability to record molecular events in vivo would enable monitoring of signaling dynamics within cellular niches and critical factors that orchestrate cellular behavior. We present a self-contained analog memory...
4.
Ma K, Perli S, Lu T
J Mol Biol
. 2016 Feb;
428(5 Pt B):893-915.
PMID: 26908220
Genetic circuits, composed of complex networks of interacting molecular machines, enable living systems to sense their dynamic environments, perform computation on the inputs, and formulate appropriate outputs. By rewiring and...
5.
Wong A, Choi G, Cui C, Pregernig G, Milani P, Adam M, et al.
Proc Natl Acad Sci U S A
. 2016 Feb;
113(9):2544-9.
PMID: 26864203
The orchestrated action of genes controls complex biological phenotypes, yet the systematic discovery of gene and drug combinations that modulate these phenotypes in human cells is labor intensive and challenging...
6.
Nissim L, Perli S, Fridkin A, Perez-Pinera P, Lu T
Mol Cell
. 2014 May;
54(4):698-710.
PMID: 24837679
RNA-based regulation and CRISPR/Cas transcription factors (CRISPR-TFs) have the potential to be integrated for the tunable modulation of gene networks. A major limitation of this methodology is that guide RNAs...
7.
Farzadfard F, Perli S, Lu T
ACS Synth Biol
. 2013 Aug;
2(10):604-13.
PMID: 23977949
Transcriptional regulation is central to the complex behavior of natural biological systems and synthetic gene circuits. Platforms for the scalable, tunable, and simple modulation of transcription would enable new abilities...