Heide Brandhorst
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Explore the profile of Heide Brandhorst including associated specialties, affiliations and a list of published articles.
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37
Citations
386
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Recent Articles
1.
Brandhorst D, Brandhorst H, Acreman S, Johnson P
Bioengineering (Basel)
. 2024 Aug;
11(8).
PMID: 39199786
Throughout the isolation process, human islets are subjected to destruction of the islet basement membrane (BM) and reduced oxygen supply. Reconstruction of the BM represents an option to improve islet...
2.
Brandhorst D, Brandhorst H, Acreman S, Johnson P
Sci Rep
. 2022 Nov;
12(1):19321.
PMID: 36369239
The impact of ischaemia can severely damage procured donor organs for transplantation. The pancreas, and pancreatic islets in particular, is one of the most sensitive tissues towards hypoxia. The present...
3.
Brandhorst D, Brandhorst H, Layland S, Acreman S, Schenke-Layland K, Johnson P
Acta Biomater
. 2021 Oct;
137:92-102.
PMID: 34653695
Enzymatic digestion of the pancreas during islet isolation is associated with disintegration of the islet basement membrane (IBM) that can cause reduction of functional and morphological islet integrity. Attempts to...
4.
Brandhorst D, Brandhorst H, Acreman S, Abraham A, Johnson P
J Inflamm Res
. 2021 Mar;
14:599-610.
PMID: 33679137
Background: Most islet transplant groups worldwide routinely use the TNFα inhibitor Etanercept in their peri-transplant protocols. Surprisingly, there have been no published dose-response studies on the effects of Etanercept on...
5.
Brandhorst H, Brandhorst D, Abraham A, Acreman S, Schive S, Scholz H, et al.
Cell Transplant
. 2020 Nov;
29:963689720952332.
PMID: 33150790
Previous studies in rodents have indicated that function and survival of transplanted islets can be substantially improved by mesenchymal stem cells (MSC). The few human islet studies to date have...
6.
Brandhorst D, Brandhorst H, Johnson P
Transplantation
. 2019 Jul;
104(2):237.
PMID: 31356576
No abstract available.
7.
Brandhorst H, Johnson P, Monch J, Kurfurst M, Korsgren O, Brandhorst D
Cell Transplant
. 2018 Nov;
28(2):176-184.
PMID: 30419762
Although human islet transplantation has been established as valid and safe treatment for patients with type 1 diabetes, the utilization rates of human pancreases for clinical islet transplantation are still...
8.
Hughes S, Bateman P, Cross S, Brandhorst D, Brandhorst H, Spiliotis I, et al.
Transplantation
. 2018 Aug;
102(11):1857-1863.
PMID: 30063695
Background: It has been proposed that islet transplants comprised primarily of small rather than large islets may provide better graft function, due to their lower susceptibility to hypoxic damage. Our...
9.
Brandhorst H, Johnson P, Korsgren O, Brandhorst D
Cell Transplant
. 2018 Jan;
26(11):1733-1741.
PMID: 29338387
Efficient islet release from the pancreas requires the combination of collagenase, neutral protease (cNP), or thermolysin (TL). Recently, it has been shown that clostripain (CP) may also contribute to efficient...
10.
Brandhorst D, Brandhorst H, Johnson P
Rev Diabet Stud
. 2017 Jun;
14(1):22-38.
PMID: 28632819
In comparison to procedures used for the separation of individual cell types from other organs, the process of human pancreatic islet isolation aims to digest the pancreatic exocrine matrix completely...