Sammanda Ramamoorthy
Overview
Explore the profile of Sammanda Ramamoorthy including associated specialties, affiliations and a list of published articles.
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43
Citations
1569
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Recent Articles
1.
Darbinian N, Merabova N, Tatevosian G, Adele S, Darbinyan A, Morrison M, et al.
Int J Mol Sci
. 2024 Nov;
25(21).
PMID: 39519122
Fetal exposures to many drugs of abuse, e.g., opioids and alcohol (EtOH), are associated with adverse neurodevelopmental problems in early childhood, including abnormalities in activity of the serotonin (5HT) transporter...
2.
Mayer F, Stewart A, Varman D, Moritz A, Foster J, Owens A, et al.
bioRxiv
. 2023 May;
PMID: 37205452
Aberrant dopamine (DA) signaling is implicated in schizophrenia, bipolar disorder (BPD), autism spectrum disorder (ASD), substance use disorder, and attention-deficit/hyperactivity disorder (ADHD). Treatment of these disorders remains inadequate, as exemplified...
3.
Varman D, Mannangatti P, Subler M, Windle J, Ramamoorthy S, Jayanthi L
J Mol Neurosci
. 2022 Jul;
72(9):1965-1976.
PMID: 35852782
Altered amine transporter function, phosphorylation, and association with interacting proteins are evident in animals with a history of psychostimulant exposure. Our previous studies have shown that the Thr258/Ser259 motif in...
4.
Goetzl L, Darbinian N, Merabova N, Devane L, Ramamoorthy S
Front Pharmacol
. 2022 Apr;
13:837694.
PMID: 35462922
Patient and providers' fear of fetal exposure to medications may lead to discontinuation of treatment, disease relapse, and maternal morbidity. Placental drug transporters play a critical role in fetal exposure...
5.
Mannangatti P, Varman D, Ramamoorthy S, Jayanthi L
Pharmacology
. 2021 Sep;
106(11-12):597-605.
PMID: 34515205
Background: Amphetamine (AMPH) and other psychostimulants act on the norepinephrine (NE) transporter (NET) and the dopamine (DA) transporter (DAT) and enhance NE and DA signaling. Both NET and DAT share...
6.
Varman D, Jayanthi L, Ramamoorthy S
Handb Exp Pharmacol
. 2021 Jun;
271:97-112.
PMID: 34136961
Dynorphin (DYN) is an endogenous neurosecretory peptide which exerts its activity by binding to the family of G protein-coupled receptors, namely the kappa opioid receptor (KOR). Opioids are associated with...
7.
Meinke C, Quinlan M, Paffenroth K, Harrison F, Fenollar-Ferrer C, Katamish R, et al.
Neurochem Res
. 2021 Apr;
47(1):37-60.
PMID: 33830406
The serotonin (5-HT) transporter (SERT) is a key regulator of 5-HT signaling and is a major target for antidepressants and psychostimulants. Human SERT coding variants have been identified in subjects...
8.
Varman D, Subler M, Windle J, Jayanthi L, Ramamoorthy S
Behav Brain Res
. 2021 Apr;
408:113267.
PMID: 33794225
Dopamine (DA) transporter (DAT) is dynamically regulated by several protein kinases and the Thr53 phosphorylation of DAT (pT53-DAT) is documented in heterologous cell models and in rat brain. However, the...
9.
Varman D, Jayanthi L, Ramamoorthy S
J Neurochem
. 2020 Aug;
156(4):445-464.
PMID: 32797733
Serotonin (5-HT) transporter (SERT) plays a crucial role in serotonergic transmission in the central nervous system, and any aberration causes serious mental illnesses. Nevertheless, the cellular mechanisms that regulate SERT...
10.
Annamalai B, Varman D, Horton R, Daws L, Jayanthi L, Ramamoorthy S
ACS Chem Neurosci
. 2020 Jan;
11(3):466-476.
PMID: 31916747
Reuptake and clearance of released serotonin (5-HT) are critical in serotonergic neurotransmission. Serotonin transporter (SERT) is mainly responsible for clearing the extracellular 5-HT. Controlled trafficking, phosphorylation, and protein stability have...