Samisubbu R Naidu
Overview
Explore the profile of Samisubbu R Naidu including associated specialties, affiliations and a list of published articles.
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13
Citations
3107
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Recent Articles
1.
Tang H, Gupta A, Morrisroe S, Bao C, Schwantes-An T, Gupta G, et al.
Circulation
. 2024 May;
150(4):302-316.
PMID: 38695173
Background: The ubiquitin-proteasome system regulates protein degradation and the development of pulmonary arterial hypertension (PAH), but knowledge about the role of deubiquitinating enzymes in this process is limited. UCHL1 (ubiquitin...
2.
Naidu S, Capitano M, Ropa J, Cooper S, Huang X, Broxmeyer H
Leukemia
. 2021 Oct;
36(3):821-833.
PMID: 34599272
Little is known of hematopoietic stem (HSC) and progenitor (HPC) cell self-renewal. The role of Brahma (BRM), a chromatin remodeler, in HSC function is unknown. Bone marrow (BM) from Brm...
3.
Babu M, Mahanta S, Lakhter A, Hato T, Paul S, Naidu S
PLoS One
. 2018 Feb;
13(2):e0191419.
PMID: 29394289
Reliance on aerobic glycolysis is one of the hallmarks of cancer. Although pyruvate kinase M2 (PKM2) is a key mediator of glycolysis in cancer cells, lack of selective agents that...
4.
Lakhter A, Naidu S
Melanoma Res
. 2017 May;
27(5):411-416.
PMID: 28489680
The universal second messenger cAMP regulates numerous cellular processes. Although the cAMP-signaling pathway leads to induction of gene transcription, it remains unknown whether this pathway contributes toward suppression of transcription....
5.
Lakhter A, Hamilton J, Konger R, Brustovetsky N, Broxmeyer H, Naidu S
J Biol Chem
. 2016 Aug;
291(42):21869-21879.
PMID: 27539851
Tumors rely on multiple nutrients to meet cellular bioenergetics and macromolecular synthesis demands of rapidly dividing cells. Although the role of glucose and glutamine in cancer metabolism is well understood,...
6.
Klionsky D, Abdelmohsen K, Abe A, Abedin M, Abeliovich H, Arozena A, et al.
Autophagy
. 2016 Jan;
12(1):1-222.
PMID: 26799652
No abstract available.
7.
Lakhter A, Lahm T, Broxmeyer H, Naidu S
J Cell Biochem
. 2015 Sep;
117(4):853-9.
PMID: 26375488
Hypoxia-inducible factor-1alpha (HIF1a) is a key transcriptional regulator that enables cellular metabolic adaptation to low levels of oxygen. Multiple mechanisms, including lysosomal degradation, control the levels of HIF1a protein. Here...
8.
Lakhter A, Hamilton J, Dagher P, Mukkamala S, Hato T, Dong X, et al.
Oncotarget
. 2015 Jan;
5(24):12694-703.
PMID: 25587028
Reliance on glycolysis is a characteristic of malignancy, yet the development of resistance to BRAF inhibitors in melanoma is associated with gain of mitochondrial function. Concurrent attenuation of oxidative phosphorylation...
9.
Lakhter A, Kanginakudru S, Warren S, Touloukian C, Boissy R, Naidu S
Melanoma Res
. 2013 Apr;
23(3):213-7.
PMID: 23624367
The tumor suppressor p53 plays a central role in preventing tumor development by promoting transcription of genes that stall cell cycle and induce cell death. Although the majority of melanomas...
10.
Lakhter A, Sahu R, Sun Y, Kaufmann W, Androphy E, Travers J, et al.
J Invest Dermatol
. 2013 Feb;
133(9):2247-54.
PMID: 23370537
The Bcl homology-3 (BH3)-only protein p53 upregulated modulator of apoptosis (PUMA) counters Bcl-2 family anti-apoptotic proteins and promotes apoptosis. Although PUMA is a key regulator of apoptosis, the post-transcriptional mechanisms...