Samir N P Kelada
Overview
Explore the profile of Samir N P Kelada including associated specialties, affiliations and a list of published articles.
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Articles
27
Citations
577
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Recent Articles
1.
Szczesny B, Boorgula M, Chavan S, Campbell M, Johnson R, Kammers K, et al.
Nat Commun
. 2024 May;
15(1):4546.
PMID: 38806494
Asthma has striking disparities across ancestral groups, but the molecular underpinning of these differences is poorly understood and minimally studied. A goal of the Consortium on Asthma among African-ancestry Populations...
2.
Tibbs T, Donoghue L, Buzzelli A, Misumi I, DeMonia M, Ferris M, et al.
iScience
. 2023 Nov;
26(11):108348.
PMID: 38026197
Zoonotic arenavirus infections can result in viral hemorrhagic disease, characterized by platelet loss, petechia, and multi-organ injury. The mechanisms governing these outcomes are likely impacted by virus strain and infection...
3.
Donoghue L, Markovetz M, Morrison C, Chen G, McFadden K, Sadritabrizi T, et al.
Am J Physiol Lung Cell Mol Physiol
. 2023 Oct;
325(6):L765-L775.
PMID: 37847709
Airway mucociliary clearance (MCC) is required for host defense and is often diminished in chronic lung diseases. Effective clearance depends upon coordinated actions of the airway epithelium and a mobile...
4.
Van Buren E, Radicioni G, Lester S, ONeal W, Dang H, Kasela S, et al.
PLoS Genet
. 2023 Jun;
19(6):e1010445.
PMID: 37352370
Hyper-secretion and/or hyper-concentration of mucus is a defining feature of multiple obstructive lung diseases, including chronic obstructive pulmonary disease (COPD). Mucus itself is composed of a mixture of water, ions,...
5.
Donoghue L, McFadden K, Vargas D, Smith G, Immormino R, Moran T, et al.
Respir Res
. 2023 Jun;
24(1):153.
PMID: 37296458
Among asthmatics, there is significant heterogeneity in the clinical presentation and underlying pathophysiological mechanisms, leading to the recognition of multiple disease endotypes (e.g., T2-high vs. T2-low). This heterogeneity extends to...
6.
Virk R, Buddenbaum N, Al-Shaer A, Armstrong M, Manke J, Reisdorph N, et al.
J Lipid Res
. 2022 Aug;
63(10):100267.
PMID: 36028048
Obesity exacerbates inflammation upon lung injury; however, the mechanisms by which obesity primes pulmonary dysregulation prior to external injury are not well studied. Herein, we tested the hypothesis that obesity...
7.
Tovar A, Smith G, Nalesnik M, Thomas J, McFadden K, Harkema J, et al.
Am J Respir Cell Mol Biol
. 2022 Jul;
67(5):528-538.
PMID: 35816602
Ozone (O)-induced respiratory toxicity varies considerably within the human population and across inbred mouse strains, indicative of gene-environment interactions (GxE). Though previous studies have identified several quantitative trait loci (QTL)...
8.
Rogers T, Button B, Kelada S, Ostrowski L, Livraghi-Butrico A, Gutay M, et al.
Front Physiol
. 2022 Mar;
13:842592.
PMID: 35356083
As the nasal cavity is the portal of entry for inspired air in mammals, this region is exposed to the highest concentration of inhaled particulate matter and pathogens, which must...
9.
Smith G, Tovar A, McFadden K, Moran T, Wagner J, Harkema J, et al.
Am J Respir Cell Mol Biol
. 2021 Dec;
65(6):672-674.
PMID: 34851239
No abstract available.
10.
Tovar A, Crouse W, Smith G, Thomas J, Keith B, McFadden K, et al.
Am J Physiol Lung Cell Mol Physiol
. 2021 Nov;
322(1):L33-L49.
PMID: 34755540
Acute ozone (O) exposure is associated with multiple adverse cardiorespiratory outcomes, the severity of which varies across individuals in human populations and inbred mouse strains. However, molecular determinants of response,...