Samantha K Barrick
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Explore the profile of Samantha K Barrick including associated specialties, affiliations and a list of published articles.
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10
Citations
137
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Recent Articles
1.
Clippinger Schulte S, Scott B, Barrick S, Stump W, Blackwell T, Greenberg M
Biophys J
. 2023 May;
122(12):2544-2555.
PMID: 37165621
The cardiac cycle is a tightly regulated process wherein the heart generates force to pump blood to the body during systole and then relaxes during diastole. Disruption of this finely...
2.
Lee L, Barrick S, Buvoli A, Walklate J, Stump W, Geeves M, et al.
J Biol Chem
. 2023 Mar;
299(5):104631.
PMID: 36963494
For decades, sarcomeric myosin heavy chain proteins were assumed to be restricted to striated muscle where they function as molecular motors that contract muscle. However, MYH7b, an evolutionarily ancient member...
3.
Barrick S, Garg A, Greenberg L, Zhang S, Lin C, Stitziel N, et al.
J Mol Cell Cardiol
. 2023 Feb;
176:58-67.
PMID: 36739943
Dilated cardiomyopathy (DCM) is a leading cause of heart failure and a major indicator for heart transplant. Human genetic studies have identified over a thousand causal mutations for DCM in...
4.
Clippinger Schulte S, Scott B, Barrick S, Stump W, Blackwell T, Greenberg M
bioRxiv
. 2023 Jan;
PMID: 36711892
Significance Statement: Human heart contraction is powered by the molecular motor β-cardiac myosin, which pulls on thin filaments consisting of actin and the regulatory proteins troponin and tropomyosin. In some...
5.
Lee L, Barrick S, Meller A, Walklate J, Lotthammer J, Tay J, et al.
J Biol Chem
. 2022 Nov;
299(1):102657.
PMID: 36334627
Myosin heavy chain 7b (MYH7b) is an evolutionarily ancient member of the sarcomeric myosin family, which typically supports striated muscle function. However, in mammals, alternative splicing prevents MYH7b protein production...
6.
Barrick S, Greenberg M
J Biol Chem
. 2021 Oct;
297(5):101297.
PMID: 34634306
Cardiac myosin is the molecular motor that powers heart contraction by converting chemical energy from ATP hydrolysis into mechanical force. The power output of the heart is tightly regulated to...
7.
Papadaki M, Kampaengsri T, Barrick S, Campbell S, von Lewinski D, Rainer P, et al.
J Mol Cell Cardiol
. 2021 Sep;
162:1-9.
PMID: 34487755
Diabetes doubles the risk of developing heart failure (HF). As the prevalence of diabetes grows, so will HF unless the mechanisms connecting these diseases can be identified. Methylglyoxal (MG) is...
8.
Barrick S, Greenberg L, Greenberg M
Mol Biol Cell
. 2021 Jun;
32(18):1677-1689.
PMID: 34161147
Dilated cardiomyopathy (DCM) is a significant cause of pediatric heart failure. Mutations in proteins that regulate cardiac muscle contraction can cause DCM; however, the mechanisms by which molecular-level mutations contribute...
9.
Barrick S, Clippinger S, Greenberg L, Greenberg M
Biophys J
. 2019 May;
116(12):2246-2252.
PMID: 31126584
Striated muscle contraction occurs when myosin thick filaments bind to thin filaments in the sarcomere and generate pulling forces. This process is regulated by calcium, and it can be perturbed...
10.
Ishiyama N, Sarpal R, Wood M, Barrick S, Nishikawa T, Hayashi H, et al.
Nat Commun
. 2018 Dec;
9(1):5121.
PMID: 30504777
α-catenin is a key mechanosensor that forms force-dependent interactions with F-actin, thereby coupling the cadherin-catenin complex to the actin cytoskeleton at adherens junctions (AJs). However, the molecular mechanisms by which...