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Sam L Koprak

Explore the profile of Sam L Koprak including associated specialties, affiliations and a list of published articles. Areas
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Articles 4
Citations 69
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Recent Articles
1.
Gu X, Dragovic J, Koo G, Koprak S, Legrand C, Mundt S, et al.
Bioorg Med Chem Lett . 2005 Sep; 15(23):5266-9. PMID: 16185866
Replacement of the pentyl chain on our original bicyclo[2.2.2]octyltriazole leads 1 and 2 has led to the discovery that heteroaryl substituted bicyclo[2.2.2]octyltriazoles are potent and selective 11beta-hydroxysteroid dehydrogenase type I...
2.
Hale J, Neway W, Mills S, Hajdu R, Keohane C, Rosenbach M, et al.
Bioorg Med Chem Lett . 2004 May; 14(12):3351-5. PMID: 15149705
Alteration in lymphocyte trafficking and prevention of graft rejection in rodents observed on exposure to FTY720 (1) or its corresponding phosphate ester 2 can be induced by the systemic administration...
3.
Middleton R, Sanchez M, Linde A, Bugianesi R, Dai G, Felix J, et al.
Biochemistry . 2003 Nov; 42(46):13698-707. PMID: 14622016
ShK, a peptide isolated from Stichodactyla helianthus venom, blocks the voltage-gated potassium channels, K(v)1.1 and K(v)1.3, with similar high affinity. ShK-Dap(22), a synthetic derivative in which a diaminopropionic acid residue...
4.
Xie J, Nomura N, Koprak S, Quackenbush E, Forrest M, Rosen H
J Immunol . 2003 Mar; 170(7):3662-70. PMID: 12646631
FTY720 (2-amino-[2-(4-octylphenyl) ethyl]-1,3-propanediol hydrochloride) is an immunosuppressive agent that inhibits allograft rejection. We recently demonstrated that FTY-phosphate, the active metabolite of FTY720, acts as a full agonist for sphingosine-1-phosphate (S1P)...