Sam Aparicio
Overview
Explore the profile of Sam Aparicio including associated specialties, affiliations and a list of published articles.
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Articles
15
Citations
1316
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0
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Recent Articles
1.
Gerbec Z, Serapio-Palacios A, Metcalfe-Roach A, Krekhno Z, Bar-Yoseph H, Woodward S, et al.
mBio
. 2025 Feb;
16(3):e0359524.
PMID: 39932300
Importance: Metastasis is a major barrier to long-term survival for cancer patients, and therapeutic options for patients with aggressive, metastatic forms of breast cancer remain limited. It is therefore critical...
2.
Widman A, Shah M, Frydendahl A, Halmos D, Khamnei C, Ogaard N, et al.
Nat Med
. 2024 Jun;
30(6):1655-1666.
PMID: 38877116
In solid tumor oncology, circulating tumor DNA (ctDNA) is poised to transform care through accurate assessment of minimal residual disease (MRD) and therapeutic response monitoring. To overcome the sparsity of...
3.
Kim M, Gorelick A, Vazquez-Garcia I, Williams M, Salehi S, Shi H, et al.
Nat Genet
. 2024 May;
56(5):889-899.
PMID: 38741018
The extent of cell-to-cell variation in tumor mitochondrial DNA (mtDNA) copy number and genotype, and the phenotypic and evolutionary consequences of such variation, are poorly characterized. Here we use amplification-free...
4.
McPherson A, Roth A, Ha G, Chauve C, Steif A, De Souza C, et al.
Genome Biol
. 2017 Oct;
18(1):188.
PMID: 28985744
No abstract available.
5.
McPherson A, Roth A, Ha G, Chauve C, Steif A, De Souza C, et al.
Genome Biol
. 2017 Jul;
18(1):140.
PMID: 28750660
Somatic evolution of malignant cells produces tumors composed of multiple clonal populations, distinguished in part by rearrangements and copy number changes affecting chromosomal segments. Whole genome sequencing mixes the signals...
6.
Khaled W, Choon Lee S, Stingl J, Chen X, Ali H, Rueda O, et al.
Nat Commun
. 2015 Jan;
6:5987.
PMID: 25574598
Triple-negative breast cancer (TNBC) has poor prognostic outcome compared with other types of breast cancer. The molecular and cellular mechanisms underlying TNBC pathology are not fully understood. Here, we report...
7.
Tubio J, Li Y, Ju Y, Martincorena I, Cooke S, Tojo M, et al.
Science
. 2014 Aug;
345(6196):1251343.
PMID: 25082706
Long interspersed nuclear element-1 (L1) retrotransposons are mobile repetitive elements that are abundant in the human genome. L1 elements propagate through RNA intermediates. In the germ line, neighboring, nonrepetitive sequences...
8.
Weaver J, Ross-Innes C, Shannon N, Lynch A, Forshew T, Barbera M, et al.
Nat Genet
. 2014 Jun;
46(8):837-843.
PMID: 24952744
Cancer genome sequencing studies have identified numerous driver genes, but the relative timing of mutations in carcinogenesis remains unclear. The gradual progression from premalignant Barrett's esophagus to esophageal adenocarcinoma (EAC)...
9.
Dvinge H, Git A, Graf S, Salmon-Divon M, Curtis C, Sottoriva A, et al.
Nature
. 2013 May;
497(7449):378-82.
PMID: 23644459
MicroRNAs (miRNAs) show differential expression across breast cancer subtypes, and have both oncogenic and tumour-suppressive roles. Here we report the miRNA expression profiles of 1,302 breast tumours with matching detailed...
10.
Mezlini A, Smith E, Fiume M, Buske O, Savich G, Shah S, et al.
Genome Res
. 2012 Dec;
23(3):519-29.
PMID: 23204306
High-throughput RNA sequencing (RNA-seq) promises to revolutionize our understanding of genes and their role in human disease by characterizing the RNA content of tissues and cells. The realization of this...