Sam Alsford
Overview
Explore the profile of Sam Alsford including associated specialties, affiliations and a list of published articles.
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Articles
40
Citations
1511
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Recent Articles
1.
Racane L, Pticek L, Kostrun S, Raic-Malic S, Taylor M, Delves M, et al.
J Med Chem
. 2023 Sep;
66(18):13043-13057.
PMID: 37722077
We designed and synthesized a series of symmetric bis-6-amidino-benzothiazole derivatives with aliphatic central units and evaluated their efficacy against bloodstream forms of the African trypanosome . Of these, a dicationic...
2.
Borg Y, Alsford S, Pavlika V, Zaikin A, Nesbeth D
Heliyon
. 2022 Feb;
8(2):e08891.
PMID: 35198764
Kinetoplastid protozoa possess properties that are highly divergent from the mammalian, yeast and bacterial cells more commonly used in synthetic biology and represent a tantalisingly untapped source of bioengineering potential....
3.
Davies C, Ooi C, Sioutas G, Hall B, Sidhu H, Butter F, et al.
Nucleic Acids Res
. 2021 Mar;
49(6):3242-3262.
PMID: 33660774
The African trypanosome Trypanosoma brucei is a unicellular eukaryote, which relies on a protective variant surface glycoprotein (VSG) coat for survival in the mammalian host. A single trypanosome has >2000...
4.
Collett C, Kitson C, Baker N, Steele-Stallard H, Santrot M, Hutchinson S, et al.
Antimicrob Agents Chemother
. 2019 Jun;
63(8).
PMID: 31160283
The arsenal of drugs used to treat leishmaniasis, caused by spp., is limited and beset by toxicity and emergent resistance. Furthermore, our understanding of drug mode of action and potential...
5.
Thomas J, Baker N, Hutchinson S, Dominicus C, Trenaman A, Glover L, et al.
PLoS Negl Trop Dis
. 2018 Nov;
12(11):e0006980.
PMID: 30475806
Chemotherapy continues to have a major impact on reducing the burden of disease caused by trypanosomatids. Unfortunately though, the mode-of-action (MoA) of antitrypanosomal drugs typically remains unclear or only partially...
6.
Decoding the network of Trypanosoma brucei proteins that determines sensitivity to apolipoprotein-L1
Currier R, Cooper A, Burrell-Saward H, MacLeod A, Alsford S
PLoS Pathog
. 2018 Jan;
14(1):e1006855.
PMID: 29346416
In contrast to Trypanosoma brucei gambiense and T. b. rhodesiense (the causative agents of human African trypanosomiasis), T. b. brucei is lysed by apolipoprotein-L1 (apoL1)-containing human serum trypanolytic factors (TLF),...
7.
Meredith E, Kumar A, Konno A, Szular J, Alsford S, Seifert K, et al.
Mol Microbiol
. 2017 Aug;
106(2):207-222.
PMID: 28792090
Quinone-based compounds have been exploited to treat infectious diseases and cancer, with such chemicals often functioning as inhibitors of key metabolic pathways or as prodrugs. Here, we screened an aziridinyl...
8.
Stortz J, Serafim T, Alsford S, Wilkes J, Fernandez-Cortes F, Hamilton G, et al.
PLoS Pathog
. 2017 Jul;
13(7):e1006477.
PMID: 28742144
All cells are subject to structural damage that must be addressed for continued growth. A wide range of damage affects the genome, meaning multiple pathways have evolved to repair or...
9.
Macedo J, Currier R, Wirdnam C, Horn D, Alsford S, Rentsch D
FASEB J
. 2017 Jul;
31(10):4649-4660.
PMID: 28679527
, protozoan parasites that cause human African trypanosomiasis (HAT), depend on ornithine uptake and metabolism by ornithine decarboxylase (ODC) for survival. Indeed, ODC is the target of the WHO "essential...
10.
Maishman L, Obado S, Alsford S, Bart J, Chen W, Ratushny A, et al.
Nucleic Acids Res
. 2016 Sep;
44(22):10554-10570.
PMID: 27625397
The nuclear lamina is a filamentous structure subtending the nuclear envelope and required for chromatin organization, transcriptional regulation and maintaining nuclear structure. The trypanosomatid coiled-coil NUP-1 protein is a lamina...