Salahuddin Mirza
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Explore the profile of Salahuddin Mirza including associated specialties, affiliations and a list of published articles.
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12
Citations
89
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Recent Articles
1.
Zhang H, Ociepa M, Nassir M, Zheng B, Lewicki S, Salmaso V, et al.
Nat Chem
. 2023 Oct;
16(2):249-258.
PMID: 37857844
Nucleoside diphosphates and triphosphates impact nearly every aspect of biochemistry; however, the use of such compounds as tools or medicinal leads for nucleotide-dependent enzymes and receptors is hampered by their...
2.
Lopez V, Schuh H, Mirza S, Vaassen V, Schmidt M, Sylvester K, et al.
Front Immunol
. 2023 Sep;
14:1173634.
PMID: 37711611
Introduction: Heparins, naturally occurring glycosaminoglycans, are widely used for thrombosis prevention. Upon application as anticoagulants in cancer patients, heparins were found to possess additional antitumor activities. Ectonucleotidases have recently been...
3.
Bi C, Schakel L, Mirza S, Sylvester K, Pelletier J, Lee S, et al.
Bioorg Chem
. 2023 Apr;
135:106460.
PMID: 37023582
Ticlopidine is an antithrombotic prodrug of the thienotetrahydropyridine family. For platelet inhibition it has to undergo oxidative ring-opening by cytochrome P450 enzymes. The resulting thiol reacts with a cysteine residue...
4.
Schakel L, Mirza S, Winzer R, Lopez V, Idris R, Al-Hroub H, et al.
J Immunother Cancer
. 2022 Aug;
10(8).
PMID: 35981785
Background: An important mechanism, by which cancer cells achieve immune escape, is the release of extracellular adenosine into their microenvironment. Adenosine activates adenosine A and A receptors on immune cells...
5.
Schakel L, Mirza S, Pietsch M, Lee S, Keuler T, Sylvester K, et al.
Arch Pharm (Weinheim)
. 2021 Oct;
354(12):e2100300.
PMID: 34697820
The antithrombotic prodrugs ticlopidine and clopidogrel are thienotetrahydro-pyridine derivatives that are metabolized in the liver to produce thiols that irreversibly block adenosine diphosphate (ADP)-activated P2Y receptors on thrombocytes. In their...
6.
Lee S, Namasivayam V, Boshta N, Perotti A, Mirza S, Bua S, et al.
RSC Med Chem
. 2021 Aug;
12(7):1187-1206.
PMID: 34355184
Nucleotide pyrophosphatase/phosphodiesterase3 (NPP3) catalyzes the hydrolysis of extracellular nucleotides. It is expressed by immune cells and some carcinomas, of kidney and colon. Together with ecto-5'-nucleotidase (CD73), NPP3 produces immunosuppressive, cancer-promoting...
7.
Breidenbach J, Lemke C, Pillaiyar T, Schakel L, Al Hamwi G, Diett M, et al.
Angew Chem Int Ed Engl
. 2021 Mar;
60(18):10423-10429.
PMID: 33655614
The main protease of SARS-CoV-2 (M ), the causative agent of COVID-19, constitutes a significant drug target. A new fluorogenic substrate was kinetically compared to an internally quenched fluorescent peptide...
8.
Lopez V, Schakel L, Schuh H, Schmidt M, Mirza S, Renn C, et al.
Mar Drugs
. 2021 Jan;
19(2).
PMID: 33499103
Extracellular ATP mediates proinflammatory and antiproliferative effects via activation of P2 nucleotide receptors. In contrast, its metabolite, the nucleoside adenosine, is strongly immunosuppressive and enhances tumor proliferation and metastasis. The...
9.
Schakel L, Schmies C, Idris R, Luo X, Lee S, Lopez V, et al.
Front Pharmacol
. 2020 Oct;
11:1294.
PMID: 33013365
Nucleoside triphosphate diphosphohydrolase1 (NTPDase1, CD39) inhibitors have potential as novel drugs for the (immuno)therapy of cancer. They increase the extracellular concentration of immunostimulatory ATP and reduce the formation of AMP,...
10.
Nassir M, Mirza S, Arad U, Lee S, Rafehi M, Attah I, et al.
Org Biomol Chem
. 2019 Nov;
17(46):9913-9923.
PMID: 31720670
Nucleotide pyrophosphatase/phosphodiesterase-1 (NPP1) inhibitors have been suggested as a potential treatment for calcium pyrophosphate dihydrate (CPPD) deposition disease. Here, we targeted the development of improved NPP1 inhibitors based on acyclic...