Sagun Jonchhe
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Explore the profile of Sagun Jonchhe including associated specialties, affiliations and a list of published articles.
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20
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138
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Recent Articles
1.
Zhu Y, Lee B, Fujii S, Jonchhe S, Zhang H, Li A, et al.
bioRxiv
. 2024 Sep;
PMID: 39253422
Highlight: Ku70 is a conserved non-homologous end-joining (NHEJ) factor. Using genetically engineered mouse models and biochemical analyses, our study uncovered a previously unappreciated role of the C-terminal SAP domain of...
2.
Pokhrel P, Karna D, Jonchhe S, Mao H
J Am Chem Soc
. 2024 May;
146(19):13046-13054.
PMID: 38710657
Common in biomacromolecules, kinetically trapped misfolded intermediates are often detrimental to the structures, properties, or functions of proteins or nucleic acids. Nature employs chaperone proteins but not nucleic acids to...
3.
Kefala Stavridi A, Gontier A, Morin V, Frit P, Ropars V, Barboule N, et al.
Nucleic Acids Res
. 2023 Oct;
51(21):11732-11747.
PMID: 37870477
The classical Non-Homologous End Joining (c-NHEJ) pathway is the predominant process in mammals for repairing endogenous, accidental or programmed DNA Double-Strand Breaks. c-NHEJ is regulated by several accessory factors, post-translational...
4.
Pokhrel P, Jonchhe S, Pan W, Mao H
J Am Chem Soc
. 2023 Jul;
145(31):17143-17150.
PMID: 37494702
Interaction between peptides and nucleic acids is a ubiquitous process that drives many cellular functions, such as replications, transcriptions, and translations. Recently, this interaction has been found in liquid-liquid phase...
5.
Vipat S, Gupta D, Jonchhe S, Anderspuk H, Rothenberg E, Moiseeva T
Nat Commun
. 2022 Nov;
13(1):7099.
PMID: 36402816
DNA polymerase epsilon (PolE) in an enzyme essential for DNA replication. Deficiencies and mutations in PolE cause severe developmental abnormalities and cancers. Paradoxically, the catalytic domain of yeast PolE catalytic...
6.
Pokhrel P, Wang J, Selvam S, Jonchhe S, Mandal S, Mao H
Biomacromolecules
. 2022 Nov;
23(11):4795-4803.
PMID: 36322676
Single-molecule methods offer high sensitivities with precisions superior to bulk assays. However, these methods are low in throughput and cannot repetitively interrogate the same cluster of molecular units. In this...
7.
Pandey S, Jonchhe S, Mishra S, Emura T, Sugiyama H, Endo M, et al.
J Phys Chem Lett
. 2022 Sep;
13(37):8692-8698.
PMID: 36094396
Cellular environments such as nanoconfinement and molecular crowding can change biomolecular properties. However, in nanoconfinement, it is extremely challenging to investigate effects of crowding cosolutes on macromolecules. By using optical...
8.
Jonchhe S, Pan W, Pokhrel P, Mao H
Angew Chem Int Ed Engl
. 2022 Mar;
61(23):e202113156.
PMID: 35320624
In Tau protein condensates formed by the Liquid-Liquid Phase Separation (LLPS) process, liquid-to-solid transitions lead to the formation of fibrils implicated in Alzheimer's disease. Here, by tracking two contacting Tau-rich...
9.
Jonchhe S, Pandey S, Beneze C, Emura T, Sugiyama H, Endo M, et al.
Nucleic Acids Res
. 2022 Jan;
50(2):697-703.
PMID: 35037040
Both ligand binding and nanocavity can increase the stability of a biomolecular structure. Using mechanical unfolding in optical tweezers, here we found that a DNA origami nanobowl drastically increased the...
10.
Hu C, Jonchhe S, Pokhrel P, Karna D, Mao H
Chem Sci
. 2021 Aug;
12(30):10159-10164.
PMID: 34377405
Mechanical unfolding of biomolecular structures has been exclusively performed at the single-molecule level by single-molecule force spectroscopy (SMFS) techniques. Here we transformed sophisticated mechanical investigations on individual molecules into a...