Sagar Ghosh
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Explore the profile of Sagar Ghosh including associated specialties, affiliations and a list of published articles.
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21
Citations
301
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Recent Articles
11.
Ghosh S, Ashcraft K
Front Biosci (Elite Ed)
. 2013 Jan;
5(2):461-78.
PMID: 23277002
Obesity is a growing epidemic all over the world that by virtue of inducation of a chronic, low-grade, and systemic inflammation leads to an increased risk of a number of...
12.
Ghosh S, Kang T, Wang H, Hu Y, Li R
Steroids
. 2011 Mar;
76(8):797-801.
PMID: 21377485
Evidence that aromatase expression in tumor-associated breast stroma is elevated, provides a rationale for use of aromatase inhibitors (AIs) in breast cancer treatment. However, regulation of local aromatase expression in...
13.
Ghosh S, Dean A, Walter M, Bao Y, Hu Y, Ruan J, et al.
Exp Cell Res
. 2010 Apr;
316(13):2087-98.
PMID: 20420826
Adipose tissue is recognized as an endocrine organ that plays an important role in human diseases such as type II diabetes and cancer. Human adipose tissue-derived stem cells (ASCs), a...
14.
Ghosh S, Hu Y, Li R
J Steroid Biochem Mol Biol
. 2009 Dec;
118(4-5):231-6.
PMID: 19969081
Obesity is associated with an increased risk of breast cancer among postmenopausal women. This is at least partly due to excessive estrogen production in adipose tissue of obese women. Aromatase,...
15.
Ghosh S, Lu Y, Hu Y
Int J Biomed Sci
. 2009 Jul;
4(4):260-265.
PMID: 19568323
Aromatase is the rate-limiting enzyme in estrogen biosynthesis and a key target in breast cancer treatment. Its ovary-specific promoter, PII, is induced in response to protein kinase A (PKA) activation....
16.
Ghosh S, Choudary A, Ghosh S, Musi N, Hu Y, Li R
Mol Endocrinol
. 2009 Feb;
23(5):662-70.
PMID: 19221050
Aromatase (Cyp19) is a key enzyme in estrogen biosynthesis and an important target in breast cancer therapy. Within tumor microenvironment, tumor cells stimulate aromatase expression in adipose stromal cells (ASCs),...
17.
Sun J, Watkins G, Blair A, Moskaluk C, Ghosh S, Jiang W, et al.
J Cell Biochem
. 2007 Oct;
103(6):1798-807.
PMID: 17910036
Cofactor of BRCA1 (COBRA1) is an integral component of the human negative elongation factor (NELF), a four-subunit protein complex that inhibits transcription elongation. Previous in vivo work indicates that COBRA1...
18.
Ghosh S, Lu Y, Katz A, Hu Y, Li R
Am J Physiol Endocrinol Metab
. 2006 Aug;
292(1):E246-52.
PMID: 16940470
Adipose tissue provides an important extragonadal source of estrogen. Obesity-associated elevation of estrogen production increases risk of breast cancer in postmenopausal women. Aromatase (CYP19), which converts androgen to estrogen, is...
19.
Hu Y, Ghosh S, Amleh A, Yue W, Lu Y, Katz A, et al.
Oncogene
. 2005 Sep;
24(56):8343-8.
PMID: 16170371
Mutations in BRCA1 increase risks of familial breast and ovarian cancers, particularly among premenopausal women. While BRCA1 plays an active role in DNA repair, this function alone may not be...
20.
Ghosh S, Wu Y, Li R, Hu Y
Oncogene
. 2005 Feb;
24(13):2236-46.
PMID: 15688015
Estrogen is critical to both normal mammary gland and breast cancer development. Circulating levels of estrogen in premenopausal women are primarily determined by the action of aromatase in ovarian granulosa...