Sachel Mok
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Explore the profile of Sachel Mok including associated specialties, affiliations and a list of published articles.
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Recent Articles
1.
Proellochs N, Andolina C, Ramjith J, Stoter R, van Gemert G, Graumans W, et al.
bioRxiv
. 2025 Jan;
PMID: 39763803
The emergence of parasites partially resistant to artemisinins (ART-R) poses a significant threat to recent gains in malaria control. ART-R has been associated with PfKelch13 (K13) mutations, which differ in...
2.
Hagenah L, Yeo T, Schindler K, Jeon J, Bloxham T, Small-Saunders J, et al.
J Infect Dis
. 2024 Dec;
PMID: 39661643
Background: Piperaquine, used in combination with dihydroartemisinin, has been identified as a promising partner drug for uncomplicated treatment and chemoprevention of Plasmodium falciparum malaria in Africa. In light of the...
3.
Luth M, Godinez-Macias K, Chen D, Okombo J, Thathy V, Cheng X, et al.
Science
. 2024 Nov;
386(6725):eadk9893.
PMID: 39607932
Surveillance of drug resistance and the discovery of novel targets-key objectives in the fight against malaria-rely on identifying resistance-conferring mutations in parasites. Current approaches, while successful, require laborious experimentation or...
4.
Kanai M, Mok S, Yeo T, Shears M, Ross L, Jeon J, et al.
bioRxiv
. 2024 Oct;
PMID: 39386571
The genetic basis of resistance to quinine (QN), a drug used to treat severe malaria, has long been enigmatic. To gain further insight, we used FRG-NOD human liver-chimeric mice to...
5.
Mok S, Yeo T, Hong D, Shears M, Ross L, Ward K, et al.
Sci Adv
. 2023 Nov;
9(45):eadi2364.
PMID: 37939186
Drug-resistant parasites have swept across Southeast Asia and now threaten Africa. By implementing a genetic cross using humanized mice, we report the identification of key determinants of resistance to artemisinin...
6.
7.
Mok S, Yeo T, Hong D, Shears M, Ross L, Ward K, et al.
bioRxiv
. 2023 Jul;
PMID: 37398288
Drug-resistant parasites have swept across Southeast Asia and now threaten Africa. By implementing a genetic cross using humanized mice, we report the identification of key determinants of resistance to artemisinin...
8.
Kumpornsin K, Kochakarn T, Yeo T, Okombo J, Luth M, Hoshizaki J, et al.
Nat Commun
. 2023 May;
14(1):3059.
PMID: 37244916
In vitro evolution of drug resistance is a powerful approach for identifying antimalarial targets, however, key obstacles to eliciting resistance are the parasite inoculum size and mutation rate. Here we...
9.
Bopp S, Pasaje C, Summers R, Magistrado-Coxen P, Schindler K, Corpas-Lopez V, et al.
Nat Commun
. 2023 Mar;
14(1):1455.
PMID: 36927839
Identifying how small molecules act to kill malaria parasites can lead to new "chemically validated" targets. By pressuring Plasmodium falciparum asexual blood stage parasites with three novel structurally-unrelated antimalarial compounds...
10.
Kucharski M, Wirjanata G, Nayak S, Boentoro J, Dziekan J, Assisi C, et al.
PLoS Pathog
. 2023 Jan;
19(1):e1011118.
PMID: 36696458
Resistance of the human malaria parasites, Plasmodium falciparum, to artemisinins is now fully established in Southeast Asia and is gradually emerging in Sub-Saharan Africa. Although nonsynonymous SNPs in the pfk13...