Sabine Huke
Overview
Explore the profile of Sabine Huke including associated specialties, affiliations and a list of published articles.
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Articles
28
Citations
1086
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0
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Recent Articles
1.
Moccetti F, Belcik T, Latifi Y, Xie A, Ozawa K, Brown E, et al.
J Am Soc Echocardiogr
. 2020 Jun;
33(8):1023-1031.e2.
PMID: 32532642
Background: Ultrasound-mediated cavitation of microbubble contrast agents produces high intravascular shear. We hypothesized that microbubble cavitation increases myocardial microvascular perfusion through shear-dependent purinergic pathways downstream from ATP release that is...
2.
Zhu Y, Shamblin I, Rodriguez E, Salzer G, Araysi L, Margolies K, et al.
Hum Mol Genet
. 2019 Dec;
29(3):369-381.
PMID: 31816043
Huntington's disease (HD) is a dominantly inherited neurodegenerative disease. There is accumulating evidence that HD patients have increased prevalence of conduction abnormalities and compromised sinoatrial node function which could lead...
3.
Jones K, Koh Y, Weller R, Turna R, Ahmad F, Huke S, et al.
Arch Biochem Biophys
. 2018 Nov;
661:125-131.
PMID: 30445044
Mutations in cardiac troponin T (TnT) associated with hypertrophic cardiomyopathy generally lead to an increase in the Ca sensitivity of contraction and susceptibility to arrhythmias. In contrast, TnT mutations linked...
4.
Yang R, Ernst P, Song J, Liu X, Huke S, Wang S, et al.
J Am Heart Assoc
. 2018 Oct;
7(15):e008939.
PMID: 30371234
Background Oxidative stress-mediated Ca/calmodulin-dependent protein kinase II (Ca MKII) phosphorylation of cardiac ion channels has emerged as a critical contributor to arrhythmogenesis in cardiac pathology. However, the link between mitochondrial-derived...
5.
6.
Huke S
J Physiol
. 2017 Feb;
595(12):3939-3947.
PMID: 28205229
The major goal of this focused review is to highlight some of the recent advances and remaining open questions about how a mutation in a myofilament protein leads to an...
7.
Xu S, Li X, LaPenna K, Yokota S, Huke S, He P
Cardiovasc Res
. 2017 Feb;
113(5):508-518.
PMID: 28158679
Aims: Fluid shear stress (SS) is known to regulate endothelial cell (EC) function. Most of the studies, however, focused on the effects of cell-free fluid-generated wall SS on ECs. The...
8.
Bovo E, Huke S, Blatter L, Zima A
J Mol Cell Cardiol
. 2017 Jan;
104:9-16.
PMID: 28131630
Functional impact of cardiac ryanodine receptor (type 2 RyR or RyR2) phosphorylation by protein kinase A (PKA) remains highly controversial. In this study, we characterized a functional link between PKA-mediated...
9.
Tardiff J, Carrier L, Bers D, Poggesi C, Ferrantini C, Coppini R, et al.
Cardiovasc Res
. 2015 Jan;
105(4):457-70.
PMID: 25634554
To date, no compounds or interventions exist that treat or prevent sarcomeric cardiomyopathies. Established therapies currently improve the outcome, but novel therapies may be able to more fundamentally affect the...
10.
Feng N, Huke S, Zhu G, Tocchetti C, Shi S, Aiba T, et al.
Proc Natl Acad Sci U S A
. 2015 Jan;
112(6):1880-5.
PMID: 25583515
BDNF and its associated tropomyosin-related kinase receptor B (TrkB) nurture vessels and nerves serving the heart. However, the direct effect of BDNF/TrkB signaling on the myocardium is poorly understood. Here...