S X Skapek
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Explore the profile of S X Skapek including associated specialties, affiliations and a list of published articles.
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20
Citations
919
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Recent Articles
1.
Skapek S, Pan Y, Lee E
Oncogene
. 2006 Aug;
25(38):5268-76.
PMID: 16936747
Early studies of the retinoblastoma gene (RB) have uncovered its critical role as a regulator of the G(1)/S cell cycle phase progression. Surprisingly, genetic approaches in mammals and nematodes have...
2.
Skapek S, Lin S, Jablonski M, McKeller R, Tan M, Hu N, et al.
Oncogene
. 2001 Dec;
20(46):6742-51.
PMID: 11709709
The differentiation of neuronal cells in the developing mammalian retina is closely coupled to cell cycle arrest and proceeds in a highly organized manner. Cyclin D1, which regulates cell proliferation...
3.
Lin S, Skapek S, Papermaster D, HANKIN M, Lee E
Oncogene
. 2001 Nov;
20(48):7073-84.
PMID: 11704831
The E2F1 transcription factor controls cell proliferation and apoptosis. E2F1 activity is negatively regulated by the retinoblastoma (RB) protein. To study how inactivation of Rb and dysregulated E2F1 affects the...
4.
Skapek S, Chui C
Curr Opin Oncol
. 2000 Jul;
12(4):315-22.
PMID: 10888416
In this past year, a large number of reports have described cytogenetic and biologic studies of sarcomas. The cytogenetic studies provide further evidence that a growing number of sarcomas seem...
5.
Skapek S, Jansen D, Wei T, McDermott T, Huang W, Olson E, et al.
J Biol Chem
. 2000 Mar;
275(10):7212-23.
PMID: 10702291
The retinoblastoma gene product, RB, seems to function as a key tumor suppressor by repressing the expression of genes activated by members of the E2F family of transcription factors. In...
6.
Skapek S, Hawk B, Hoffer F, Dahl G, Granowetter L, Gebhardt M, et al.
J Clin Oncol
. 1998 Sep;
16(9):3021-7.
PMID: 9738571
Purpose: We report the treatment of 10 children for progressive desmoid tumor not amenable to standard surgical or radiation therapy with the use of vinblastine (VBL) and methotrexate (MTX). Patients...
7.
Skapek S, Shaffer L, Barker J
Curr Opin Oncol
. 1998 Aug;
10(4):318-25.
PMID: 9702399
Recently, much research has been directed toward gaining a better understanding of sarcoma biology. To accomplish this goal, researchers have focused on characterizing the cytogenetic abnormalities that are detectable by...
8.
Parsons S, Skapek S, Neufeld E, Kuhlman C, Young M, Donnelly M, et al.
Blood
. 1997 Mar;
89(6):1886-95.
PMID: 9058708
To further elucidate the incidence and potential mechanism of asparaginase-associated lipid abnormalities in children with acute lymphoblastic leukemia (ALL), we serially obtained fasting lipid and lipoprotein studies on 38 of...
9.
Skapek S, Rhee J, Kim P, Novitch B, Lassar A
Mol Cell Biol
. 1996 Dec;
16(12):7043-53.
PMID: 8943359
It was recently demonstrated that ectopic expression of cyclin D1 inhibits skeletal muscle differentiation and, conversely, that expression of cyclin-dependent kinase (cdk) inhibitors facilitates activation of this differentiation program (S....
10.
Lin S, Skapek S, Lee E
Semin Cancer Biol
. 1996 Oct;
7(5):279-89.
PMID: 9110405
The retinoblastoma susceptibility gene (RB), the first identified human tumor suppressor gene, has been shown to be directly involved in the genesis of a variety of human cancers. RB is...