S R Hubbard
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Explore the profile of S R Hubbard including associated specialties, affiliations and a list of published articles.
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30
Citations
2798
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Recent Articles
1.
Favelyukis S, Till J, Hubbard S, Miller W
Nat Struct Biol
. 2001 Nov;
8(12):1058-63.
PMID: 11694888
The insulin-like growth factor 1 (IGF1) receptor is closely related to the insulin receptor. However, the unique biological functions of IGF1 receptor make it a target for therapeutic intervention in...
2.
Hubbard S
Mol Cell
. 2001 Oct;
8(3):481-2.
PMID: 11583608
Huse et al. in this issue of Molecular Cell and Wybenga-Groot et al. in the September 21, 2001 issue of Cell present biochemical and structural studies that elucidate the roles...
3.
Stein E, Gustafson T, Hubbard S
FEBS Lett
. 2001 Apr;
493(2-3):106-11.
PMID: 11287005
Grb7, Grb10 and Grb14 comprise a family of adaptor proteins that interact with numerous receptor tyrosine kinases upon receptor activation. Between the pleckstrin homology (PH) domain and the Src homology...
4.
Parang K, Till J, Ablooglu A, Kohanski R, Hubbard S, Cole P
Nat Struct Biol
. 2001 Jan;
8(1):37-41.
PMID: 11135668
Protein kinase inhibitors have applications as anticancer therapeutic agents and biological tools in cell signaling. Based on a phosphoryl transfer mechanism involving a dissociative transition state, a potent and selective...
5.
Till J, Ablooglu A, Frankel M, Bishop S, Kohanski R, Hubbard S
J Biol Chem
. 2001 Jan;
276(13):10049-55.
PMID: 11124964
The tyrosine kinase domain of the insulin receptor is subject to autoinhibition in the unphosphorylated basal state via steric interactions involving the activation loop. A mutation in the activation loop...
6.
Hubbard S, Till J
Annu Rev Biochem
. 2000 Aug;
69:373-98.
PMID: 10966463
Tyrosine phosphorylation is one of the key covalent modifications that occurs in multicellular organisms as a result of intercellular communication during embryogenesis and maintenance of adult tissues. The enzymes that...
7.
Laird A, Vajkoczy P, Shawver L, Thurnher A, Liang C, Mohammadi M, et al.
Cancer Res
. 2000 Aug;
60(15):4152-60.
PMID: 10945623
Vascular endothelial growth factor, fibroblast growth factor (FGF), and platelet-derived growth factor (PDGF) and their cognate receptor tyrosine kinases are strongly implicated in angiogenesis associated with solid tumors. Using rational...
8.
Ablooglu A, Till J, Kim K, Parang K, Cole P, Hubbard S, et al.
J Biol Chem
. 2000 Jun;
275(39):30394-8.
PMID: 10869355
The interaction of a synthetic tetrafluorotyrosyl peptide substrate with the activated tyrosine kinase domain of the insulin receptor was studied by steady-state kinetics and x-ray crystallography. The pH-rate profiles indicate...
9.
Plotnikov A, Hubbard S, Schlessinger J, Mohammadi M
Cell
. 2000 Jun;
101(4):413-24.
PMID: 10830168
To elucidate the structural determinants governing specificity in fibroblast growth factor (FGF) signaling, we have determined the crystal structures of FGF1 and FGF2 complexed with the ligand binding domains (immunoglobulin-like...
10.
Mandiyan V, ANDREEV J, Schlessinger J, Hubbard S
EMBO J
. 1999 Dec;
18(24):6890-8.
PMID: 10601011
ADP ribosylation factors (ARFs), which are members of the Ras superfamily of GTP-binding proteins, are critical components of vesicular trafficking pathways in eukaryotes. Like Ras, ARFs are active in their...