S P SCOTT
Overview
Explore the profile of S P SCOTT including associated specialties, affiliations and a list of published articles.
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Articles
13
Citations
227
Followers
0
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Recent Articles
1.
SCOTT S, Weber I, Harrison R, Carey J, Tanaka J
Biochemistry
. 2001 Jun;
40(25):7464-73.
PMID: 11412099
The eukaryotic cyclic nucleotide-gated (CNG) ion channels are a family of large membrane proteins activated by cytoplasmic cGMP or cAMP. Their cyclic nucleotide-binding domain is structurally homologous with that of...
2.
Gatei M, SCOTT S, Filippovitch I, Soronika N, Lavin M, Weber B, et al.
Cancer Res
. 2000 Jun;
60(12):3299-304.
PMID: 10866324
The human genetic disorder ataxia-telangiectasia is characterized by immunodeficiency, progressive cerebellar ataxia, radiosensitivity, cell cycle checkpoint defects, and cancer predisposition. The gene product [ataxia-telangiectasia mutation (ATM)] mutated in this syndrome...
3.
SCOTT S, Cummings J, Joe J, Tanaka J
Biophys J
. 2000 Apr;
78(5):2321-33.
PMID: 10777730
Cyclic nucleotide-gated (CNG) channels, which were initially studied in retina and olfactory neurons, are activated by cytoplasmic cGMP or cAMP. Detailed comparisons of nucleotide-activated currents using nucleotide analogs and mutagenesis...
4.
Zhou B, Chaturvedi P, Spring K, SCOTT S, Johanson R, Mishra R, et al.
J Biol Chem
. 2000 Apr;
275(14):10342-8.
PMID: 10744722
Recent evidence indicates that arrest of mammalian cells at the G(2)/M checkpoint involves inactivation and translocation of Cdc25C, which is mediated by phosphorylation of Cdc25C on serine 216. Data obtained...
5.
Chen P, Gatei M, Oconnell M, Khanna K, Bugg S, Hogg A, et al.
Oncogene
. 1999 Feb;
18(1):249-56.
PMID: 9926940
Cells from patients with the human genetic disorder ataxia-telangiectasia (A-T) are defective in the activation of cell cycle checkpoints in response to ionizing radiation damage. In order to understand the...
6.
SCOTT S, Tanaka J
Biochemistry
. 1998 Dec;
37(49):17239-52.
PMID: 9860838
Cytoplasmic cAMP and cGMP are soluble cellular messengers that directly activate cyclic nucleotide-gated (CNG) channels. These channels mediate sensory transduction in photoreceptors and olfactory neurons. The closely related CNG channels...
7.
8.
SCOTT S, Zhang N, Khanna K, Khromykh A, Hobson K, Watters D, et al.
Biochem Biophys Res Commun
. 1998 May;
245(1):144-8.
PMID: 9535798
The gene mutated in the human genetic disorder ataxia-telangiectasia, ATM, is implicated in the response to radiation-induced DNA damage and to a more widespread signalling defect. The ATM protein is...
9.
Navaratnam D, Su H, SCOTT S, Oberholtzer J
Nat Med
. 1996 Oct;
2(10):1136-9.
PMID: 8837614
Loss of receptor hair cells in the cochlea accounts for a significant proportion of hearing impairment in the population. Hair cells can be lost as a consequence of viral or...
10.
SCOTT S, Harrison R, Weber I, Tanaka J
Protein Eng
. 1996 Apr;
9(4):333-44.
PMID: 8738209
Cyclic nucleotide-gated channels (CNGC) open in response to the binding of 3'5'-cyclic nucleotides. Members of the CNGC family vary as much as 100-fold in their ability to respond to cAMP...