S P H Alexander
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Explore the profile of S P H Alexander including associated specialties, affiliations and a list of published articles.
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25
Citations
1653
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Recent Articles
1.
Donovan J, Wong P, Garle M, Alexander S, Dunn W, Ralevic V
Acta Physiol (Oxf)
. 2018 Jun;
224(4):e13126.
PMID: 29896909
Aim: Hypoxia causes vasodilatation of coronary arteries which protects the heart from ischaemic damage through mechanisms including the generation of hydrogen sulphide (H S), but the influence of the perivascular...
2.
Donovan J, Wong P, Roberts R, Garle M, Alexander S, Dunn W, et al.
Vascul Pharmacol
. 2017 May;
93-95:20-32.
PMID: 28552745
Hypoxia-induced coronary artery vasodilatation protects the heart by increasing blood flow under ischemic conditions, however its mechanism is not fully elucidated. Hydrogen sulfide (HS) is reported to be an oxygen...
3.
McGrath J, Pawson A, Sharman J, Alexander S
Br J Pharmacol
. 2015 May;
172(12):2929-32.
PMID: 25965085
Linked Editorials: This Editorial is part of a series. To view the other Editorials in this series, visit: http://onlinelibrary.wiley.com/doi/10.1111/bph.12956/abstract; http://onlinelibrary.wiley.com/doi/10.1111/bph.12954/abstract; http://onlinelibrary.wiley.com/doi/10.1111/bph.12955/abstract and http://onlinelibrary.wiley.com/doi/10.1111/bph.12856/abstract. Video: To view the video on the...
4.
Alefishat E, Alexander S, Ralevic V
Purinergic Signal
. 2014 Oct;
11(1):47-57.
PMID: 25315718
Nicotinamide adenine dinucleotide (NAD) belongs to the family of naturally occurring adenine dinucleotides, best known for their various intracellular roles. However, there is evidence that they can also be released...
5.
Wong P, Garle M, Alexander S, Randall M, Roberts R
Pharmacol Res
. 2014 Sep;
90:25-35.
PMID: 25258292
Hydrogen peroxide (H2O2) has been proposed to act as a factor for endothelium-derived hyperpolarization (EDH) and EDH may act as a 'back up' system to compensate the loss of the...
6.
Roberts R, Allen S, Chang A, Henderson H, Hobson G, Karania B, et al.
Toxicol Appl Pharmacol
. 2013 Jul;
272(3):797-805.
PMID: 23845591
German chamomile (Matricaria recutita L.), a widely-used herbal medicine, has been reported to have a wide range of biological effects, including smooth muscle relaxation. The aim of this study was...
7.
Alefishat E, Alexander S, Ralevic V
Br J Pharmacol
. 2012 Dec;
168(8):1911-22.
PMID: 23215951
Background And Purpose: Acyl derivatives of CoA have been shown to act as antagonists at human platelet and recombinant P2Y1 receptors, but little is known about their effects in the...
8.
Rashid S, Heer J, Garle M, Alexander S, Roberts R
Br J Pharmacol
. 2012 Dec;
168(8):1902-10.
PMID: 23215842
Background And Purpose: Hydrogen sulphide (H2S) is an endogenous gasotransmitter. Although it has been shown to elicit responses in vascular and other smooth muscle preparations, a role for endogenously produced...
9.
Woodhams S, Wong A, Barrett D, Bennett A, Chapman V, Alexander S
Br J Pharmacol
. 2012 Aug;
167(8):1609-19.
PMID: 22924700
Background And Purpose: The cannabinoid receptor-mediated analgesic effects of 2-arachidonoylglycerol (2-AG) are limited by monoacylglycerol lipase (MAGL). 4-nitrophenyl 4-[bis (1,3-benzodioxol-5-yl) (hydroxy) methyl] piperidine-1-carboxylate (JZL184) is a potent inhibitor of MAGL...
10.
Alexander S
Br J Pharmacol
. 2011 Oct;
165(8):2411-3.
PMID: 22014123
The further characterization of the orphan GPCR GPR18 conducted by McHugh et al. in this issue of the British Journal of Pharmacology has generated a pharmacological profile that raises some...