S M Lea
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Explore the profile of S M Lea including associated specialties, affiliations and a list of published articles.
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5
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669
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Recent Articles
1.
Hollingshead S, Jongerius I, Exley R, Johnson S, Lea S, Tang C
Nat Commun
. 2018 Mar;
9(1):1051.
PMID: 29535307
There is an urgent need to develop vaccines against pathogenic bacteria. However, this is often hindered by antigenic diversity and difficulties encountered manufacturing membrane proteins. Here we show how to...
2.
Blanc E, Roversi P, Vonrhein C, Flensburg C, Lea S, Bricogne G
Acta Crystallogr D Biol Crystallogr
. 2004 Dec;
60(Pt 12 Pt 1):2210-21.
PMID: 15572774
BUSTER-TNT is a maximum-likelihood macromolecular refinement package. BUSTER assembles the structural model, scales observed and calculated structure-factor amplitudes and computes the model likelihood, whilst TNT handles the stereochemistry and NCS...
3.
Lukacik P, Roversi P, White J, Esser D, Smith G, Billington J, et al.
Proc Natl Acad Sci U S A
. 2004 Jan;
101(5):1279-84.
PMID: 14734808
The human complement regulator CD55 is a key molecule protecting self-cells from complement-mediated lysis. X-ray diffraction and analytical ultracentrifugation data reveal a rod-like arrangement of four short consensus repeat (SCR)...
4.
Fry E, Lea S, Jackson T, Newman J, Ellard F, Blakemore W, et al.
EMBO J
. 1999 Feb;
18(3):543-54.
PMID: 9927414
Heparan sulfate has an important role in cell entry by foot-and-mouth disease virus (FMDV). We find that subtype O1 FMDV binds this glycosaminoglycan with a high affinity by immobilizing a...
5.
Lea S, Powell R, McKee T, Evans D, Brown D, Stuart D, et al.
J Biol Chem
. 1998 Nov;
273(46):30443-7.
PMID: 9804811
The biochemical properties of the molecular interactions mediating viral-cell recognition are poorly characterized. In this study, we use surface plasmon resonance to study the affinity and kinetics of the interaction...