S M Kakonen
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Explore the profile of S M Kakonen including associated specialties, affiliations and a list of published articles.
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9
Citations
92
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Recent Articles
1.
Luukinen H, Kakonen S, Pettersson K, Koski K, Laippala P, Lovgren T, et al.
J Bone Miner Res
. 2000 Dec;
15(12):2473-8.
PMID: 11127212
We examined serum total osteocalcin (TOC), carboxylated osteocalcin (COC), and their ratio (COC/TOC) by one-step two-site immunofluorescent assays in 87% (n = 792) of all home-dwelling persons of 70 years...
2.
Kakonen S, Hellman J, Karp M, Laaksonen P, Obrant K, Vaananen H, et al.
Clin Chem
. 2000 Mar;
46(3):332-7.
PMID: 10702519
Background: Circulating human osteocalcin (hOC) has been used as a marker of bone formation. Our aim was to validate three immunofluorometric assays (IFMAs), measuring different forms of hOC. Methods: The...
3.
Obrant K, Kakonen S, Astermark J, Lilja H, Lovgren T, Akesson K, et al.
J Bone Miner Res
. 1999 May;
14(4):555-60.
PMID: 10234576
We assessed the serum concentration of gamma-carboxylated osteocalcin (OC), total OC, and full-length OC in a clinical setting of 37 patients on continuous warfarin treatment (international normalized ratio 2.0-3.8). A...
4.
Halleen J, Karp M, Viloma S, Laaksonen P, Hellman J, Kakonen S, et al.
J Bone Miner Res
. 1999 Feb;
14(3):464-9.
PMID: 10027912
Tartrate-resistant acid phosphatase (TRAP), an enzyme expressed in bone-resorbing osteoclasts, is secreted into the circulation during bone resorption. We used six monoclonal antibodies (MAbs) to optimize direct two-site fluoroimmunoassays for...
5.
Matikainen T, Kakonen S, Pettersson K, Karp M, Lovgren T, Vaananen H, et al.
J Bone Miner Res
. 1999 Feb;
14(3):431-8.
PMID: 10027908
We have isolated and characterized human osteocalcin (OC) fragments from pubertal urine. The fragments were isolated by immunoaffinity chromatography based on monoclonal antibody 6F9 and further purified by reverse phase...
6.
Ylikoski A, Hellman J, Matikainen T, Kakonen S, Karp M, Vaananen H, et al.
J Bone Miner Res
. 1998 Jul;
13(7):1183-90.
PMID: 9661083
Circulating human osteocalcin (hOC) has been shown to be comprised of two main forms: the intact 1-49 form and the proteolytic N-terminal midfragment (N-mid) spanning amino acid residues 1-43 or...
7.
Halleen J, Hentunen T, Karp M, Kakonen S, Pettersson K, Vaananen H
J Bone Miner Res
. 1998 Apr;
13(4):683-7.
PMID: 9556068
Osteoclasts secrete tartrate-resistant acid phosphatase (TRAP) to the circulation, where the amount of TRAP is expected to correlate with the bone resorption rate. We have developed two monoclonal antibodies, O1A...
8.
Kakonen S, Hellman J, Pettersson K, Lovgren T, Karp M
Protein Expr Purif
. 1996 Sep;
8(2):137-44.
PMID: 8812845
Human osteocalcin (hOC) is a 49-amino-acid peptide produced mainly by bone osteoblasts. The amount of hOC in the circulation reflects the status of bone metabolism and it is used to...
9.
Hellman J, Kakonen S, Matikainen M, Karp M, Lovgren T, Vaananen H, et al.
J Bone Miner Res
. 1996 Aug;
11(8):1165-75.
PMID: 8854253
Nine monoclonal antibodies (Mabs) were raised against human recombinant osteocalcin fusion protein (rGST-hOC) or bovine osteocalcin (bOC) and selected to develop two-site immunoassays for human osteocalcin (hOC). The detection system...