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S K Hanks

Explore the profile of S K Hanks including associated specialties, affiliations and a list of published articles. Areas
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Articles 45
Citations 5582
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Recent Articles
1.
Rivera G, Antoku S, Gelkop S, Shin N, Hanks S, Pawson T, et al.
Proc Natl Acad Sci U S A . 2006 Jun; 103(25):9536-41. PMID: 16769879
The Nck family of Src homology (SH) 2/SH3 domain adaptors functions to link tyrosine phosphorylation induced by extracellular signals with downstream regulators of actin dynamics. We investigated the role of...
2.
Ruest P, Shin N, Polte T, Zhang X, Hanks S
Mol Cell Biol . 2001 Oct; 21(22):7641-52. PMID: 11604500
Tyrosine phosphorylation of CAS (Crk-associated substrate, p130(Cas)) has been implicated as a key signaling step in integrin control of normal cellular behaviors, including motility, proliferation, and survival. Aberrant CAS tyrosine...
3.
Wang H, Dembo M, Hanks S, Wang Y
Proc Natl Acad Sci U S A . 2001 Sep; 98(20):11295-300. PMID: 11572981
Focal adhesion kinase (FAK) is a non-receptor protein tyrosine kinase localized at focal adhesions and is believed to mediate adhesion-stimulated effects. Although ablation of FAK impairs cell movement, it is...
4.
Maru Y, Hanks S, Shibuya M
Biochim Biophys Acta . 2001 Aug; 1540(2):147-53. PMID: 11513976
Focal adhesion kinase (FAK) is known to be located at the intersection between extracellular matrix and growth factor signaling pathways to regulate cell motility. We have shown previously that an...
5.
Sonoda Y, Matsumoto Y, Funakoshi M, Yamamoto D, Hanks S, Kasahara T
J Biol Chem . 2000 May; 275(21):16309-15. PMID: 10821872
Focal adhesion kinase (FAK) has an anti-apoptotic role in anchorage-dependent cells via an unknown mechanism. To elucidate the role of FAK in anti-apoptosis, we have established several FAK cDNA-transfected HL-60...
6.
DONALDSON J, Dempsey P, Reddy S, Bouton A, Coffey R, Hanks S
Exp Cell Res . 2000 Mar; 256(1):168-78. PMID: 10739664
Crk-associated substrate (p130(Cas), Cas) is a docking protein first recognized as having elevated phosphotyrosine content in mammalian cells transformed by v-Src and v-Crk oncoproteins. Subsequent studies have implicated Cas in...
7.
Ruest P, Roy S, Shi E, Mernaugh R, Hanks S
Cell Growth Differ . 2000 Feb; 11(1):41-8. PMID: 10672902
Focal adhesion kinase (FAK) is a key signaling molecule regulating cellular responses to integrin-mediated adhesion. Integrin engagement promotes FAK phosphorylation at multiple sites to achieve full FAK activation. Phosphorylation of...
8.
Zhang X, Chattopadhyay A, Ji Q, OWEN J, Ruest P, Carpenter G, et al.
Proc Natl Acad Sci U S A . 1999 Aug; 96(16):9021-6. PMID: 10430888
The nonreceptor tyrosine kinase FAK ("focal adhesion kinase") is a key mediator of integrin signaling events controlling cellular responses to the extracellular matrix, including spreading, migration, proliferation, and survival. Integrin-ligand...
9.
OWEN J, Ruest P, FRY D, Hanks S
Mol Cell Biol . 1999 Jun; 19(7):4806-18. PMID: 10373530
Focal adhesion kinase (FAK) is a nonreceptor protein tyrosine kinase involved in integrin-mediated control of cell behavior. Following cell adhesion to components of the extracellular matrix, FAK becomes phosphorylated at...
10.
Yamakita Y, Totsukawa G, Yamashiro S, Fry D, Zhang X, Hanks S, et al.
J Cell Biol . 1999 Jan; 144(2):315-24. PMID: 9922457
At mitosis, focal adhesions disassemble and the signal transduction from focal adhesions is inactivated. We have found that components of focal adhesions including focal adhesion kinase (FAK), paxillin, and p130(CAS)...